In an attempt to form 2-alkylidene-1,3-oxazolidines, chiral 2-oxazolines have been N-alkylated and N-acylated. Two new N-methyloxazolinium salts have been prepared and characterized, but alkaline treatment resulted in their decomposition. In contrast, attempts to isolate three N-benzoyloxazolinium salts gave the products of their ring hydrolysis: unsymmetrically diacylated amino alcohols whose structure was confirmed by X-ray diffraction in one case. Overall the method allows stepwise regiospecific N,O-diacylation of 2-amino alcohols.

中文翻译：

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N-酰基恶唑啉鎓盐的生成和水解可实现手性氨基醇的区域特异性酰化

为了形成2-亚烷基-1，3-恶唑烷，手性2-恶唑啉已被N-烷基化和N-酰化。已经制备并表征了两种新的N-甲基恶唑啉鎓盐，但是碱处理导致它们分解。相反，尝试分离出三种N-苯甲酰恶唑啉鎓盐会产生其环水解的产物：一种是通过X射线衍射证实其结构的不对称二酰化氨基醇。总之，该方法允许2-氨基醇的逐步区域特异性的N，O-二酰化。