Ion channels of viruses (viroporins) represent a common type of protein targets for drugs. The relative simplicity of channel architecture allows convenient computational modeling and enables virtual search for new inhibitors. In this review, we analyze the data published over the last 10 years on known ion channels of viruses that cause socially significant diseases. The effectiveness of inhibition by various types of heterocyclic compounds of the viroporins of influenza virus, hepatitis С virus, human immunodeficiency virus, human papillomaviruses, coronaviruses, and respiratory syncytial virus is discussed. The presented material highlights the promise held by the search for heterocyclic antiviral compounds that act by inhibition of viroporins.

中文翻译：

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抗病毒化合物设计中的 Viroporins 杂环抑制剂。

病毒的离子通道（病毒孔蛋白）代表了药物的常见蛋白质靶标类型。通道架构的相对简单性允许方便的计算建模并能够虚拟搜索新的抑制剂。在这篇综述中，我们分析了过去 10 年发表的关于已知病毒离子通道的数据，这些病毒会导致具有社会意义的重大疾病。讨论了各种杂环化合物对流感病毒、丙型肝炎病毒、人类免疫缺陷病毒、人乳头瘤病毒、冠状病毒和呼吸道合胞病毒的病毒孔蛋白的抑制效果。所呈现的材料强调了寻找通过抑制病毒孔蛋白起作用的杂环抗病毒化合物所带来的希望。