This review article is devoted to the so-called fleximer nucleoside analogs, containing two or more planar moieties in the heterocyclic base, connected by a bond that permits rotation. Such analogs have been proposed as molecular probes for detecting enzyme–substrate interactions and studying the transcription and translation of nucleic acids, but subsequently have attracted the interest of researchers by their antiviral and antitumor activity. The methods used in the synthesis of such compounds, along with their structural features and also biological activity are considered in this review.

中文翻译：

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具有 Fleximer 核碱基的核苷类似物。

这篇综述文章专门讨论所谓的弗莱西默核苷类似物，它在杂环碱基中包含两个或多个平面部分，通过允许旋转的键连接。此类类似物已被提议作为分子探针，用于检测酶-底物相互作用以及研究核酸的转录和翻译，但随后因其抗病毒和抗肿瘤活性而引起了研究人员的兴趣。本综述考虑了此类化合物的合成方法及其结构特征和生物活性。