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A Delta-Opioid Receptor Gene Polymorphism Moderates the Therapeutic Response to Extended-Release Buprenorphine in Opioid Use Disorder.
International Journal of Neuropsychopharmacology ( IF 4.5 ) Pub Date : 2020-09-13 , DOI: 10.1093/ijnp/pyaa069
Henry R Kranzler 1 , Kevin G Lynch 1, 2 , Richard C Crist 3 , Emily Hartwell 1, 2 , Anne Le Moigne 4 , Celine M Laffont 4 , Anne C Andorn 4
Affiliation  

Buprenorphine treatment is not equally effective in all patients with opioid use disorder (OUD). Two retrospective studies showed that, among African Americans (AAs), rs678849, a polymorphism in the delta-opioid receptor gene, moderated the therapeutic effect of sublingual buprenorphine.

中文翻译:


Delta-阿片受体基因多态性调节阿片类药物使用障碍中缓释丁丙诺啡的治疗反应。



丁丙诺啡治疗并非对所有阿片类药物使用障碍 (OUD) 患者都同样有效。两项回顾性研究表明,在非裔美国人 (AA) 中,δ-阿片受体基因的 rs678849 多态性可调节舌下含服丁丙诺啡的治疗效果。
更新日期:2020-09-13
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