DNMT1 maintains the methylation of miR ‐152‐3p to regulate TMSB10 expression, thereby affecting the biological characteristics of colorectal cancer cells,IUBMB Life

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DNMT1 maintains the methylation of miR ‐152‐3p to regulate TMSB10 expression, thereby affecting the biological characteristics of colorectal cancer cells
IUBMB Life ( IF 3.7 ) Pub Date : 2020-09-12 , DOI: 10.1002/iub.2366
Chenchen Wang _{1,

2} , Xiaoji Ma _{2,

3} , Jieyun Zhang _{1,

2} , Xiaobin Jia ₄ , Mingzhu Huang _{1,

2}

Affiliation

DNA methyltransferases (DNMTs) take on a relevant role in epigenetic control of cancer proliferation and cell survival. However, the molecular mechanisms underlying the establishment and maintenance of DNA methylation in human cancer remain to be fully elucidated. This study was to investigate that how DNMT1 affected the biological characteristics of colorectal cancer (CRC) cells via modulating methylation of microRNA (miR)‐152‐3p and thymosin β 10 (TMSB10) expression.

中文翻译：

DNMT1维持miR-152-3p的甲基化以调节TMSB10的表达，从而影响结直肠癌细胞的生物学特性

DNA 甲基转移酶 (DNMT) 在癌症增殖和细胞存活的表观遗传控制中发挥相关作用。然而，人类癌症中 DNA 甲基化的建立和维持的分子机制仍有待充分阐明。本研究旨在探讨 DNMT1 如何通过调节 microRNA (miR)-152-3p 和胸腺素 β10 (TMSB10) 表达的甲基化影响结直肠癌 (CRC) 细胞的生物学特性。

更新日期：2020-09-12

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