As the primary catalyst of homologous recombination (HR) in vertebrates, RAD51 has been extensively studied in the context of repair of double-stranded DNA breaks (DSBs). With recent advances in the understanding of RAD51 function extending beyond DSBs, the importance of RAD51 throughout DNA metabolism has become increasingly clear. Here we review the suggested roles of RAD51 beyond HR, specifically focusing on their interplay with DNA replication and the maintenance of genomic stability, in which RAD51 function emerges as a double-edged sword.

中文翻译：

---

RAD51：超越休息

作为脊椎动物同源重组 (HR) 的主要催化剂，RAD51 在修复双链 DNA 断裂 (DSB) 的背景下得到了广泛的研究。随着对 RAD51 功能理解的最新进展超越了 DSB，RAD51 在整个 DNA 代谢中的重要性变得越来越清晰。在这里，我们回顾了 RAD51 在 HR 之外的建议作用，特别关注它们与 DNA 复制和维持基因组稳定性的相互作用，其中 RAD51 功能是一把双刃剑。