Acute exercise increases circulating IGF-1 in Alzheimer's disease patients, but not in older adults without dementia.,Behavioural Brain Research

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Acute exercise increases circulating IGF-1 in Alzheimer's disease patients, but not in older adults without dementia.
Behavioural Brain Research ( IF 2.6 ) Pub Date : 2020-09-13 , DOI: 10.1016/j.bbr.2020.112903
Angelica Miki Stein ₁ , Thays Martins Vital da Silva ₂ , Flávia Gomes de Melo Coelho ₃ , André Veloso Rueda ₄ , Rosana Camarini ₄ , Ruth Ferreira Santos Galduróz ₅

Affiliation

Objectives

Increased Insulin-like growth factor I (IGF-1) has been associated with improvement of cognitive function in response to exercise. Evidences indicate a role for IGF-1 in beta-amyloid clearance and reducing hyperphosphorylation tau in Alzheimer’s disease (AD). There is a need to investigate the IGF-1 response to exercise in AD patients due to well-known potential effects of exercise on IGF-1. The aim of this study was to examine circulating IGF-1 levels in AD patients and older adults without dementia after acute exercise and to verify the associations among cardiorespiratory fitness, cognition and IGF-1 levels.

Method

Seventy-four older adults (40 older adults without dementia and 34 AD patients) participated in this study. The outcomes included IGF-1 plasma levels and performance in the submaximal exercise stress test. Secondary outcomes included cognitive functions, depressive symptoms, level of physical activity, insulin-resistance, and cholesterol. All participants performed the incremental test on a treadmill and IGF-1 was collected before and after the exercise.

Results

A tendency to the difference of baseline IGF-1 plasma levels between the groups was found. After the acute exercise AD patients also presented higher levels of circulating IGF-1 compared to the Older adults without dementia. Correlations among cardiorespiratory fitness and cognitive functions were found.

Conclusion

The findings suggest that AD patients and older adults respond differently to acute exercise in terms of circulating IGF-1 levels. This response seems to indicate either an IGF-1 resistance or a compensatory exercise-induced to lower IGF-1 levels in AD patients. Cardiorespiratory fitness is associated with global cognition, executive function, attention and information processing speed.

中文翻译：

急性运动会增加阿尔茨海默病患者的 IGF-1 循环，但不会增加没有痴呆症的老年人。

目标

增加的胰岛素样生长因子 I (IGF-1) 与运动后认知功能的改善有关。证据表明 IGF-1 在 β-淀粉样蛋白清除和降低阿尔茨海默病 (AD) 中过度磷酸化 tau 中的作用。由于众所周知的运动对 IGF-1 的潜在影响，有必要研究 AD 患者中 IGF-1 对运动的反应。本研究的目的是检查急性运动后 AD 患者和没有痴呆的老年人的循环 IGF-1 水平，并验证心肺健康、认知和 IGF-1 水平之间的关联。