The identification and characterization of variables that influence “liking” and enhance vulnerability to repeated alcohol use are vital to understanding and treating alcohol use disorders. In the current study, we explore the influence of rearing environment and experimenter-administered adolescent ethanol on the hedonic value of ethanol, sucrose, and quinine. Male and female rats were reared for 30 days starting at postnatal day (PND) 21 in either an enriched, isolated, or standard condition and received 1.5 g/kg (intraperitoneally [i.p.]) 20% (w/v) ethanol or saline every other day for 12 days starting at PND 28. Thereafter, all rats had indwelling intraoral fistulae implanted and their taste reactivities to water, ethanol (5, 10, 20, 30, 40% v/v), sucrose (0.1, 0.25, 0.5 M), and quinine (0.1, 0.5 mM) were recorded and analyzed. Results indicated that enrichment elevated hedonic responding to sucrose compared to isolation, and induced a stronger negative relationship between hedonic responding and ethanol concentration compared to standard conditions. Enrichment also elevated aversive responding to ethanol and quinine compared to both isolated and standard condition rats. Adolescent ethanol injections marginally reduced aversive responding to quinine. These results replicate previous findings that environmental enrichment enhances both “liking” and aversion. In addition, the current findings suggest that, while adolescent ethanol injections may blunt aversive responses to quinine, they have no effect on aversive or hedonic responding to ethanol or sucrose. Together with existing literature, our results may suggest that experience with the taste of ethanol is necessary for alterations to ethanol “liking” and aversion.

识别和表征影响“喜欢”并增强反复饮酒易感性的变量对于理解和治疗酒精使用障碍至关重要。在目前的研究中，我们探讨了饲养环境和实验者施用的青少年乙醇对乙醇、蔗糖和奎宁的享乐价值的影响。从出生后第 21 天开始，雄性和雌性大鼠在富集、分离或标准条件下饲养 30 天，并且每一次接受 1.5 g/kg（腹膜内 [ip]）20% (w/v) 乙醇或生理盐水另一天从 PND 28 开始，持续 12 天。此后，所有大鼠都植入了留置的口腔内瘘，并且它们对水、乙醇（5、10、20、30、40% v/v）、蔗糖（0.1、0.25、0.5）的味觉反应性M) 和奎宁 (0.1, 0.5 mM) 被记录和分析。结果表明，与分离相比，富集提高了对蔗糖的快感反应，并且与标准条件相比，在快感反应和乙醇浓度之间产生了更强的负相关。与孤立的和标准条件的大鼠相比，富集还提高了对乙醇和奎宁的厌恶反应。青少年乙醇注射略微降低了对奎宁的厌恶反应。这些结果重复了之前的发现，即环境丰富会增强“喜欢”和厌恶。此外，目前的研究结果表明，虽然青少年乙醇注射可能会减弱对奎宁的厌恶反应，但它们对乙醇或蔗糖的厌恶或快感反应没有影响。结合现有文献，