We investigated the palliative effect of Artemisia judaica extract (AjE) on testicular deterioration induced by DM in high-fat diet/streptozocin (HFD/STZ)-injected rats. Forty rats were allocated to the following five groups: control, AjE, HFD/STZ, HFD/STZ-AjE, and HFD/STZ-metformin. HFD/STZ-diabetic rats showed a marked decrease in testicular weight and male sex hormones. There was significant suppression of testicular antioxidant enzymes and glutathione content in HFD/STZ-diabetic rats. However, rats that had received the STZ injection and the high-fat diet displayed increased malondialdehyde content and nitric oxide levels as well as tumour necrosis factor-alpha. High levels of Bax and low levels of Bcl-2 were detected after the STZ injection. Obvious pathological alterations were found in the testicular tissue of the HFD/STZ-diabetic rats. Thus, the administration of AjE attenuated the biochemical, molecular, and histopathological changes in the testes of the diabetic rats. The obtained findings showed that AjE treatment attenuated the diabetes-induced reprotoxicity in male rats via its antioxidant, anti-inflammatory, and antiapoptotic properties.

我们调查了蒿蒿的姑息作用提取物（AjE）对高脂饮食/链脲佐菌素（HFD / STZ）注射的大鼠DM引起的睾丸退化的影响。40只大鼠被分为以下五个组：对照组，AjE，HFD / STZ，HFD / STZ-AjE和HFD / STZ-二甲双胍。患有HFD / STZ的糖尿病大鼠睾丸重量和雄性激素显着降低。在HFD / STZ糖尿病大鼠中，睾丸抗氧化酶和谷胱甘肽含量受到显着抑制。但是，接受STZ注射和高脂饮食的大鼠显示丙二醛含量和一氧化氮水平升高，以及肿瘤坏死因子-α升高。STZ注射后检测到高水平的Bax和低水平的Bcl-2。在HFD / STZ-糖尿病大鼠的睾丸组织中发现了明显的病理改变。因此，AjE的给药减弱了生化反应，糖尿病大鼠睾丸的分子和组织病理学变化。获得的发现表明，AjE治疗通过其抗氧化，抗炎和抗凋亡特性减弱了糖尿病引起的雄性大鼠再毒性。