A multifunctional nanodrug, PAMAM@CuS-HA-RB/DOX, was prepared for the real time tracking and chemo-photothermal therapy of tumor cells. The CuS nanoclusters with diameter less than 10[Formula: see text]nm could be easily ingested by tumor cells and showed good colloid stability and high photothermal conversion efficiency. The hyaluronic acid (HA) coating and rhodamine B (RB) labeling endowed the nanocomposite with low cytotoxity and real time fluorescence imaging ability. In the acidic tumor microenvironment, the doxorubicin linked via the pH-responsive hydrazone bonds was released and worked synergistically with CuS to kill the tumor cells, which showed a high chemo-photothermal therapy capacity. All these properties indicated the PAMAM@CuS-HA-RB/DOX have promising application for the therapy of cancers and tracking of nanodrugs.

中文翻译：

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用于癌症荧光成像和化学光热治疗的小型多功能 CuS 纳米团簇的制备

制备了一种多功能纳米药物 PAMAM@CuS-HA-RB/DOX，用于肿瘤细胞的实时跟踪和化学光热治疗。直径小于10[公式：见正文]nm的CuS纳米团簇易于被肿瘤细胞摄取，表现出良好的胶体稳定性和较高的光热转化效率。透明质酸 (HA) 涂层和罗丹明 B (RB) 标记赋予纳米复合材料低细胞毒性和实时荧光成像能力。在酸性肿瘤微环境中，通过pH响应性腙键连接的多柔比星被释放，并与CuS协同作用杀死肿瘤细胞，显示出较高的化学-光热治疗能力。所有这些特性表明 PAMAM@CuS-HA-RB/DOX 在癌症治疗和纳米药物追踪方面具有广阔的应用前景。