Pain is the most common symptom in patients with rheumatoid arthritis (RA). Although in recent years, through the implementation of targeted treatment and the introduction of disease-modifying antirheumatic drugs (DMARDs), the treatment of RA patients has made a significant progress, a large proportion of patients still feel pain. Finding appropriate treatment to alleviate the pain is very important for RA patients. Current research showed that, in addition to inflammation, RA pain involves peripheral sensitization and abnormalities in the central nervous system (CNS) pain regulatory mechanisms. This review summarized the literature on pain mechanisms of RA published in recent years. A better understanding of pain mechanisms will help to develop new analgesic targets and deploy new and existing therapies.

中文翻译：

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类风湿性关节炎的疼痛机制：从细胞因子到中枢致敏

疼痛是类风湿性关节炎 (RA) 患者最常见的症状。尽管近年来通过靶向治疗的实施和疾病缓解抗风湿药物（DMARDs）的引入，RA患者的治疗取得了显着进展，但仍有很大比例的患者感到疼痛。寻找合适的治疗方法来减轻疼痛对 RA 患者来说非常重要。目前的研究表明，除炎症外，RA 疼痛还涉及外周敏化和中枢神经系统 (CNS) 疼痛调节机制的异常。本综述总结了近年来发表的关于 RA 疼痛机制的文献。更好地了解疼痛机制将有助于开发新的镇痛目标并部署新的和现有的疗法。