ABSTRACT

Introduction

Epilepsy, a major neurological disorder affects about 1% of the Indian population. The discovery of noninvasive strategies for epilepsy presents a challenge for the scientists. Different types of nose-to-brain dosage-forms have been studied for epilepsy management. It aims to give new perspectives for developing new and existing anti-epileptic drugs. Combining nanotechnology with nose-to-brain approach can help in promoting the treatment efficacy by site-specific delivery. Also, it will minimize the side-effects and patient noncompliance observed in conventional administration routes. Peptide delivery can be an interesting approach for the management of epilepsy. Drug-loaded intranasal nanoformulations exhibit diverse prospective potentials in the management of epilepsy. Considering that, nanotherapy using nose-to-brain delivery as a prospective technique for the efficient management of epilepsy is reviewed.

Areas covered

The authors have compiled all recently available data pertaining to the nose-to-brain delivery of therapeutics using nanotechnological strategies. The fundamental mechanism of nose-to-brain delivery, claims for intranasal delivery and medical devices for epilepsy are discussed.

Expert opinion

Drug-loaded intranasal nanoformulations exhibit different prospective potentials in the management of epilepsy. Considering the foregoing research done in the field of nanotechnology, globally, authors propose nose-to-brain delivery of nanoformulations as a potential technique for the efficient management of epilepsy.

中文翻译：

---

使用基于纳米技术的鼻对脑药物递送策略管理癫痫病

抽象的

介绍

癫痫病是一种主要的神经系统疾病，约占印度人口的1％。癫痫非侵入性策略的发现对科学家提出了挑战。已经研究了不同类型的鼻-脑剂型用于癫痫治疗。它旨在为开发新的和现有的抗癫痫药提供新的见解。将纳米技术与鼻－脑方法相结合可以通过特定部位的递送来帮助提高治疗效果。而且，它将最小化常规给药途径中观察到的副作用和患者不依从性。肽递送可以是用于治疗癫痫的一种有趣的方法。载有药物的鼻内纳米制剂在癫痫的治疗中展现出各种潜在的潜力。考虑到这一点，

覆盖区域

作者已经使用纳米技术策略汇编了所有最近可用的有关鼻腔至脑部治疗的数据。讨论了鼻到脑分娩的基本机制，鼻内分娩的索赔以及癫痫的医疗器械。

专家意见

药物装载的鼻内纳米制剂在癫痫的治疗中表现出不同的前瞻性潜力。考虑到上述在纳米技术领域中进行的研究，全球范围内，作者提出了将纳米制剂从鼻到脑输送作为有效治疗癫痫的潜在技术。