Abstract

Objective

The aim of the study is to find the prevalence and incidence of amyotrophic lateral sclerosis in Antalya and to define patient characteristics.

Methods

The study represents five major districts in the Antalya metropolitan region, with a population of 1,286,943, which is defined as the provincial center. In cooperation with the neurology departments of all hospitals and private practices, existing cases were identified and new cases were recorded with continuous monitoring. Detailed demographic and clinical features of each patient were recorded, Revised El-Escorial Criteria were used for diagnosis. Incidence and prevalence rates are standardized by age based on USA 2016 population.

Results

Point prevalence rates of 2016, 2017 and 2018 are 3.7, 4.7 and 5.4 per hundred thousand, respectively. Standardized prevalence rates for the US population are 5.5, 7.1 and 8.6 per hundred thousand in the same order. The incidence rate in 2017 is 1.4 per hundred thousand, and 2018 is 1.2. Standardized incidence rates for the US population are 2.1 and 1.8 per hundred thousand, respectively. About 75.6% of the cases were classified as definite, 11.0% probable, 11.0% possible, 2.4% probable laboratory-supported. The male/female ratio is 2.0 for total cases and 2.8 for new cases. The site of onset is spinal in 81.7% of patients and bulbar in 18.3%.

Conclusions

ALS rates detected in Antalya and the general features of the disease show similarities with European countries rather than Asian countries and comply with the literature.

中文翻译：

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土耳其安塔利亚的肌萎缩侧索硬化症。一项前瞻性研究，2016-2018

摘要

客观的

该研究的目的是找出安塔利亚肌萎缩侧索硬化的患病率和发病率，并确定患者的特征。

方法

该研究代表了安塔利亚大都市区的五个主要地区，人口为 1,286,943，被定义为省中心。与所有医院和私人诊所的神经科合作，确定现有病例并记录新病例并持续监测。记录了每位患者的详细人口统计学和临床​​特征，使用修订的 El-Escorial 标准进行诊断。发病率和患病率根据美国 2016 年人口按年龄进行标准化。

结果

2016年、2017年和2018年的点流行率分别为3.7、4.7和5.4‰。美国人口的标准化流行率为每十万人 5.5、7.1 和 8.6，按相同顺序排列。2017年发病率为1.4‰，2018年为1.2‰。美国人口的标准化发病率分别为每十万分之 2.1 和 1.8。大约 75.6% 的病例被归类为确定的，11.0% 的可能，11.0% 的可能，2.4% 的可能实验室支持。总病例的男女比例为 2.0，新病例为 2.8。81.7% 的患者起病部位为脊柱，18.3% 的患者起病部位为延髓。

结论

在安塔利亚检测到的 ALS 率和该疾病的一般特征与欧洲国家而非亚洲国家相似，并且与文献相符。