This study shows no association between sleep duration, sleep quality, or insomnia with the risk of overall ovarian cancer among postmenopausal women. However, restful sleep quality was associated with a lower risk of invasive serous ovarian cancer, and insomnia was associated with a higher risk of invasive serous ovarian cancer. Several studies have assessed the relationship between sleep duration and ovarian cancer risk, but the results are conflicting. Importantly, no studies addressed the relationship between sleep disturbance or sleep quality and ovarian cancer incidence. Moreover, few studies have examined the relationships between sleep measures and subtypes of ovarian cancer. This study included 109,024 postmenopausal women ages 50–79 from the Women's Health Initiative during 1993–1998 and followed through 2018. The Cox proportional hazards model was used to estimate adjusted HRs for the associations between sleep habits and the incidence of ovarian cancer and its subtypes. No association was observed between sleep duration, sleep quality, sleep disturbance, or insomnia and risk of overall ovarian cancer, serous/nonserous, or type I/type II ovarian cancer subtype. However, compared with women with average sleep quality, women with restful or very restful sleep quality had a significantly lower risk of invasive serous subtype [HR: 0.73, 95% confidence interval (CI): 0.60–0.90] while insomnia was associated with a higher risk of invasive serous subtype (HR: 1.36, 95% CI: 1.12–1.66). Associations with insomnia differed significantly by serous and nonserous subtypes, and type I and type II subtypes (Pheterogeneity = 0.001 and Pheterogeneity <0.001, respectively). This study provides no evidence on association between sleep habits and overall ovarian cancer risk among postmenopausal women. However, restful or very restful sleep quality was associated with a lower risk of invasive serous ovarian cancer, and insomnia was associated with a higher risk of invasive serous ovarian cancer. Associations with insomnia differed by subtypes. Prevention Relevance: This study shows no association between sleep duration, sleep quality, or insomnia with the risk of overall ovarian cancer among postmenopausal women. However, restful sleep quality was associated with a lower risk of invasive serous ovarian cancer, and insomnia was associated with a higher risk of invasive serous ovarian cancer.

中文翻译：

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绝经后妇女的睡眠特征和卵巢癌风险

这项研究表明，绝经后妇女的睡眠时间、睡眠质量或失眠与整体卵巢癌的风险无关。然而，安宁的睡眠质量与较低的浸润性浆液性卵巢癌风险相关，而失眠与较高的浸润性浆液性卵巢癌风险相关。几项研究评估了睡眠时间与卵巢癌风险之间的关系，但结果相互矛盾。重要的是，没有研究涉及睡眠障碍或睡眠质量与卵巢癌发病率之间的关系。此外，很少有研究检查睡眠测量与卵巢癌亚型之间的关系。这项研究包括 109,024 名 50-79 岁的绝经后妇女，这些妇女在 1993-1998 年和 2018 年期间来自妇女健康倡议。Cox比例风险模型用于估计睡眠习惯与卵巢癌及其亚型发病率之间关联的调整后HR。未观察到睡眠持续时间、睡眠质量、睡眠障碍或失眠与总体卵巢癌、浆液性/非浆液性或 I 型/II 型卵巢癌亚型风险之间存在关联。然而，与睡眠质量一般的女性相比，睡眠质量安宁或非常安宁的女性患侵袭性浆液性亚型的风险显着降低 [HR：0.73，95% 置信区间 (CI)：0.60-0.90]，而失眠与侵袭性浆液性亚型的风险更高（HR：1.36，95% CI：1.12-1.66）。与失眠的关联在浆液性和非浆液性亚型以及 I 型和 II 型亚型之间存在显着差异（异质性 = 0.001 和异质性 <0.001，分别）。这项研究没有提供任何证据表明绝经后妇女的睡眠习惯与总体卵巢癌风险之间存在关联。然而，安宁或非常安宁的睡眠质量与较低的浸润性浆液性卵巢癌风险相关，而失眠与较高的浸润性浆液性卵巢癌风险相关。与失眠的关联因亚型而异。预防相关性：这项研究表明，绝经后妇女的睡眠时间、睡眠质量或失眠与整体卵巢癌的风险无关。然而，安宁的睡眠质量与较低的浸润性浆液性卵巢癌风险相关，而失眠与较高的浸润性浆液性卵巢癌风险相关。这项研究没有提供任何证据表明绝经后妇女的睡眠习惯与总体卵巢癌风险之间存在关联。然而，安宁或非常安宁的睡眠质量与较低的浸润性浆液性卵巢癌风险相关，而失眠与较高的浸润性浆液性卵巢癌风险相关。与失眠的关联因亚型而异。预防相关性：这项研究表明，绝经后妇女的睡眠时间、睡眠质量或失眠与整体卵巢癌的风险无关。然而，安宁的睡眠质量与较低的浸润性浆液性卵巢癌风险相关，而失眠与较高的浸润性浆液性卵巢癌风险相关。这项研究没有提供任何证据表明绝经后妇女的睡眠习惯与总体卵巢癌风险之间存在关联。然而，安宁或非常安宁的睡眠质量与较低的浸润性浆液性卵巢癌风险相关，而失眠与较高的浸润性浆液性卵巢癌风险相关。与失眠的关联因亚型而异。预防相关性：这项研究表明，绝经后妇女的睡眠时间、睡眠质量或失眠与整体卵巢癌的风险无关。然而，安宁的睡眠质量与较低的浸润性浆液性卵巢癌风险相关，而失眠与较高的浸润性浆液性卵巢癌风险相关。安宁或非常安宁的睡眠质量与较低的浸润性浆液性卵巢癌风险相关，而失眠与较高的浸润性浆液性卵巢癌风险相关。与失眠的关联因亚型而异。预防相关性：这项研究表明，绝经后妇女的睡眠时间、睡眠质量或失眠与整体卵巢癌的风险无关。然而，安宁的睡眠质量与较低的浸润性浆液性卵巢癌风险相关，而失眠与较高的浸润性浆液性卵巢癌风险相关。安宁或非常安宁的睡眠质量与较低的浸润性浆液性卵巢癌风险相关，而失眠与较高的浸润性浆液性卵巢癌风险相关。与失眠的关联因亚型而异。预防相关性：这项研究表明，绝经后妇女的睡眠时间、睡眠质量或失眠与整体卵巢癌的风险无关。然而，安宁的睡眠质量与较低的浸润性浆液性卵巢癌风险相关，而失眠与较高的浸润性浆液性卵巢癌风险相关。或失眠与绝经后妇女整体卵巢癌的风险。然而，安宁的睡眠质量与较低的浸润性浆液性卵巢癌风险相关，而失眠与较高的浸润性浆液性卵巢癌风险相关。或失眠与绝经后妇女整体卵巢癌的风险。然而，安宁的睡眠质量与较低的浸润性浆液性卵巢癌风险相关，而失眠与较高的浸润性浆液性卵巢癌风险相关。