The present study focused on an investigation of significant electrospinning parameters on Mg‐doped fluorapatite nanoparticles‐poly (ε‐caprolactone) fibrous nanocomposite scaffold (Mg‐FA NPs/PCL). Since there are many factors that could have an influence on electrospinning process, Taguchi experimental design approach was used to reduce the number of experiments. The selected parameters included the concentration of polymer, solvent system, ceramic concentration, applied voltage, and the distance between nozzle and collector. The analysis of variance (ANOVA) showed that, among the studied parameters, polymer concentration and type of solvent had the most significant effect on the consistency of the solution which played a major role in producing uniform non‐beaded fibers. In order to maximize performance of electrospun scaffold, the surface tension should be kept minimizing by decreasing concentration, applying a high dielectric solvent system, increasing voltage, and declining distance in a very stable electrical field. Eventually, the optimum condition to fabricate Mg‐FA NPs/PCL fibrous scaffold was electrospinning 10 wt% PCL with 1 wt% Mg‐FA NPs solution in chloroform by applying 20 kV into 20 cm distance. According to the bioactivity and cell attachment results, the electrospun Mg‐FA NPs/PCL is suggested as a promising candidate for tissue engineering, especially for bone tissue.

中文翻译：

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实施Taguchi方法以分析静电纺丝参数对掺Mg的氟磷灰石纳米颗粒-聚（ε-己内酯）纳米复合支架（Mg-FA NPs / PCL）性能的影响

本研究的重点是对掺Mg的氟磷灰石纳米粒子-聚（ε己内酯）纤维纳米复合支架（Mg-FA NPs / PCL）。由于有许多因素可能影响静电纺丝工艺，因此田口实验设计方法用于减少实验次数。选择的参数包括聚合物的浓度，溶剂体系，陶瓷的浓度，施加的电压以及喷嘴与收集器之间的距离。方差分析（ANOVA）表明，在所研究的参数中，聚合物浓度和溶剂类型对溶液的稠度影响最大，这对生产均匀的非串珠纤维起着重要作用。为了使电纺支架的性能最大化，应通过降低浓度，施加高介电溶剂体系，增加电压，并且在非常稳定的电场中距离逐渐减小。最终，制造Mg-FA NPs / PCL纤维支架的最佳条件是通过在20 cm距离内施加20 kV电压，将10 wt％PCL与1 wt％Mg-FA NPs溶液在氯仿中静电纺丝。根据生物活性和细胞附着结果，建议将电纺Mg-FA NPs / PCL作为组织工程特别是骨组织的有希望的候选者。