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Leukocyte immunoglobulin-like receptor B1 and B4 (LILRB1 and LILRB4): Highly sensitive and specific markers of acute myeloid leukemia with monocytic differentiation
Cytometry Part B: Clinical Cytometry ( IF 3.4 ) Pub Date : 2020-09-12 , DOI: 10.1002/cyto.b.21952
Hywyn R O Churchill 1 , Franklin S Fuda 1 , Jing Xu 1 , Mi Deng 2 , Cheng Cheng Zhang 2 , Zhiqiang An 3 , Ningyan Zhang 3 , Pu Chen 4 , Colin Bergstrom 5 , Ankit Kansagra 5 , Robert Collins 5 , Samuel John 6 , Prasad Koduru 1 , Weina Chen 1
Affiliation  

Acute myeloid leukemia (AML) with monocytic differentiation (M-AML) remains a diagnostic challenge largely due to lack of sensitive and specific markers for immature monocytes. The immunoglobulin-like inhibitory receptors, LILRB1 and LILRB4, are expressed on monocytes but have not yet been systematically evaluated in the clinical setting.

中文翻译:

白细胞免疫球蛋白样受体 B1 和 B4(LILRB1 和 LILRB4):具有单核细胞分化的急性髓性白血病的高度敏感和特异性标志物

具有单核细胞分化 (M-AML) 的急性髓性白血病 (AML) 仍然是一个诊断挑战,主要是由于缺乏对未成熟单核细胞的敏感和特异性标志物。免疫球蛋白样抑制受体 LILRB1 和 LILRB4 在单核细胞上表达,但尚未在临床环境中进行系统评估。
更新日期:2020-09-12
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