An efficient metal‐free approach has been devised towards the synthesis of azoles via C−H insertion protocol. Various isocyanides were examined as effective C1‐synthons. The HFIP plays crucial role as hydrogen source and promoter of the reaction in order to reveal the maximum efficacies to accomplish the transformation in high yields of the products with excellent functional group tolerance. The control experiment affirmed 83% of deuterium incorporation, when the reaction was performed using HFIP‐d₂.

中文翻译：

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结合使用HFIP和异氰酸酯的简便的C–H插入策略：无金属获得偶氮衍生物

已经设计出一种有效的无金属方法，可通过CH插入方案合成唑类。检查了各种异氰酸酯作为有效的C1合成子。HFIP作为氢源和反应促进剂起着至关重要的作用，以揭示最大的效率，以高收率完成具有优异官能团耐受性的产品的转化。当使用HFIP- d ₂进行反应时，对照实验确认了83％的氘掺入。