A rhodium-catalyzed [4+1] annulation between 2-aryl quinazolin-4(3H)-ones and sulfoxonium ylides was developed, leading to 12-aroyl isoindolo[1,2-b]quinazolin-10(12H)-ones in moderate to good yields. This reaction proceeds with sequential ortho-CH functionalization of 2-aryl quinazolin-4(3H)-ones and an intramolecular rhodium-catalyzed α-amination of carbonyl to furnish the cyclization. This procedure was applied to access some 13-aroyl luotonin A derivatives whereby the direct construction of ring c.

中文翻译：

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铑催化的亚砜基鎓盐的[4 + 1]环合反应：顺式-C H官能化/羰基α-胺化成多环喹唑啉酮

开发了铑催化的2-芳基喹唑啉-4（3 H）-酮与亚砜基砜之间的[4 + 1]环化反应，从而制得12-芳基异吲哚并[1,2 - b ]喹唑啉-10（12 H）-中等至高产的玉米。该反应以2-芳基喹唑啉-4（3H）-的顺序邻位C H官能化和分子内铑催化的羰基α-氨基化以提供环化作用而进行。将该方法用于获得一些13-芳酰基荧光素A衍生物，由此直接构建环c。