Wenyujindiol A (1), a new sesquiterpene possessing a skeleton with a rare 4/8 ring system, together with the known compound (4S,5S)-germacrone-4,5-epoxide (2), were isolated from the rhizomes of Curcuma wenyujin. The structure of 1 was elucidated using spectroscopic measurements and single-crystal X-ray diffraction experiments. A plausible biogenetic pathway was also proposed for the biosynthesis of 1 from farnesyl diphosphate (FPP). Biological evaluation indicated that 1 exhibited moderate antitumor activity on the human breast cancer cell line MCF-7.

中文翻译：

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温榆金二醇A，一种来自姜黄温榆金的根茎的新倍半萜

从根茎中分离出一种新的倍半萜烯-一种具有稀有4/8环系统骨架的新倍萜烯-文育金二醇A（1）和已知的化合物（4 S，5 S）-Germacrone-4,5-epoxy（2）。的温郁金。使用光谱测量和单晶X射线衍射实验阐明了1的结构。还提出了从二磷酸法呢基酯（FPP）生物合成1的可行生物遗传途径。生物学评估表明1对人乳腺癌细胞MCF-7具有中等的抗肿瘤活性。