Tandem water electrolysis for the transformation of universal feedstock to value-added chemicals integrated with hydrogen generation and in situ utilization is a promising approach to address the economic challenges of electrochemical hydrogen evolution and storage. Herein, we present the controllable electrocatalytic deuteration of halides using inexpensive and reusable heavy water (D₂O) as a D-source for the preparation of valuable D-labelled chemicals and pharmaceuticals under mild conditions. This electrochemical deuteration method with high efficiency and selectivity furnishes a series of D-labelled chemicals and pharmaceuticals in high yields with excellent D-incorporation. The reaction efficiency and selectivity, that is, the precise substitution of deuterium atoms at different halogen positions, can be tuned by varying the applied voltages. The results show the great potential of green and economical electrocatalytic methods for producing value-added fine chemicals in addition to hydrogen evolution.

用于将通用原料转化为与氢气生成和原位利用相结合的增值化学品的串联水电解是解决电化学氢析出和储存的经济挑战的有前途的方法。在此，我们提出了使用廉价且可重复使用的重水 (D ₂O) 作为 D 源，用于在温和条件下制备有价值的 D 标记化学品和药物。这种具有高效率和选择性的电化学氘化方法以高产率提供了一系列 D 标记的化学品和药物，并具有出色的 D 掺入。反应效率和选择性，即氘原子在不同卤素位置的精确取代，可以通过改变施加的电压来调节。结果表明，除了析氢之外，绿色和经济的电催化方法在生产高附加值精细化学品方面具有巨大潜力。