Multiple sclerosis is an inflammatory and neurodegenerative disease of the central nervous system in which the immune cells attack the myelin sheath of the nerves, leading to axonal damage, inflammation, immune cell infiltration, and demyelination of the brain and spinal cord. These detrimental changes cause some impairments, such as depression, motor deficit, and cognitive dysfunction, affecting the quality of life in MS patients and their social activities. The present study assessed the impact of 6-week voluntary exercise prior to disease onset on the expression of Nrf-2, IL-10, IL-17, as well as the degree of lymphocyte infiltration in the spinal cord and disease severity in the chronic period of the EAE (30 days post-induction). The results showed that voluntary wheel running stimulated the expression of Nrf-2 and IL-10, while decreased the expression of IL-17, the rate of lymphocyte infiltration, and the severity of EAE at the chronic period of the disease. Thus, alterations in lifestyle, such as regular exercise, may modulate inflammation and disease severity in patients with MS.

多发性硬化症是中枢神经系统的炎症和神经退行性疾病，其中免疫细胞攻击神经的髓鞘，导致轴突损伤，炎症，免疫细胞浸润以及大脑和脊髓脱髓鞘。这些有害的变化会导致某些障碍，例如抑郁，运动障碍和认知功能障碍，影响MS患者的生活质量及其社交活动。本研究评估了发病前6周的自愿运动对Nrf-2，IL-10，IL-17的表达以及慢性淋巴细胞在脊髓中的浸润程度和疾病严重程度的影响EAE期间（诱导后30天）。结果表明，自愿轮转刺激了Nrf-2和IL-10的表达，在慢性病期间，IL-17的表达，淋巴细胞浸润率和EAE严重程度降低。因此，生活方式的改变，例如定期运动，可能会调节MS患者的炎症和疾病严重程度。