Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Modulatory effect of methylsulfonylmethane against BPA/γ-radiation induced neurodegenerative alterations in rats: Influence of TREM-2/DAP-12/Syk pathway
Life Sciences ( IF 5.2 ) Pub Date : 2020-09-12 , DOI: 10.1016/j.lfs.2020.118410 Mohamed K Abdel-Rafei 1 , Noura M Thabet 1
Life Sciences ( IF 5.2 ) Pub Date : 2020-09-12 , DOI: 10.1016/j.lfs.2020.118410 Mohamed K Abdel-Rafei 1 , Noura M Thabet 1
Affiliation
|
Methylsulfonylmethane (MSM), is an organosulfur compound, has many health benefits. Bisphenol-A (BPA) and γ-radiation (R) are two risky environmental contaminants that human beings are exposed to in everyday life. This work aims at unveiling the modulatory role of MSM in combating BPA and R co-exposure induced neurodegenerative disorder (Alzheimer's (AD)-mimic neurotoxicity). Female rats were randomly divided into five groups. One group was normal control and the other four groups were subjected to subacute BPA intoxication and/or exposed to fractionated weekly doses of R for 4 weeks and either untreated or treated with MSM concomitantly. BPA and R co-exposure induced typical hallmarks of neurodegenerative disorders as revealed by tremendously elevated oxidative stress, extensive neuroinflammation (tumor necrosis factor –α and interleukin-1β), elevated AD markers (amyloid-beta (Aβ), acetylcholinesterase (AchE) activity and tau-phosphorylation) in cortex and hippocampus as well as up-regulation of microglial pro-inflammatory triggering receptor expressed on myeloid cell-2(TREM-2)/DNAX-activating protein of 12 kDa (DAP-12)/spleen-tyrosine kinase (Syk) pathway and its downstream targets (PLC-γ/DAG/p38-MAPK) in hippocampus. Also, neurodegenerative lesions were revealed in histopathological examination of cortex and hippocampus coupled with marked Aβ deposition in hippocampus. Whereas, MSM treatment improved histopathological insults and ameliorated level of oxidative stress, neuroinflammation and AD markers as well as modulated TREM-2/DAP-12/Syk pathway. Our data suggest that MSM afforded neuroprotection against BPA and R; supporting its potential application in the associated neurodegenerative disorders.
中文翻译：
甲基磺酰甲烷对 BPA/γ 辐射诱导的大鼠神经退行性改变的调节作用：TREM-2/DAP-12/Syk 通路的影响
甲基磺酰甲烷 (MSM) 是一种有机硫化合物，具有许多健康益处。双酚 A (BPA) 和 γ 辐射 (R) 是人类在日常生活中接触的两种危险环境污染物。这项工作旨在揭示 MSM 在对抗 BPA 和 R 共同暴露引起的神经退行性疾病（阿尔茨海默病 (AD) 模拟神经毒性）中的调节作用。雌性大鼠被随机分为五组。一组为正常对照，其他四组接受亚急性 BPA 中毒和/或暴露于每周分次剂量的 R，持续 4 周，并且不治疗或同时接受 MSM 治疗。 BPA 和 R 共同暴露会诱发神经退行性疾病的典型特征，表现为氧化应激大幅升高、广泛的神经炎症（肿瘤坏死因子 -α 和白细胞介素 1β）、AD 标志物（淀粉样蛋白 -β (Aβ)、乙酰胆碱酯酶 (AchE) 活性升高）和 tau 磷酸化）以及在髓样细胞 2 (TREM-2)/12 kDa DNAX 激活蛋白 (DAP-12)/脾酪氨酸上表达的小胶质细胞促炎触发受体的上调海马激酶 (Syk) 通路及其下游靶标 (PLC-γ/DAG/p38-MAPK)。此外，皮层和海马的组织病理学检查显示神经退行性病变，并伴有海马中明显的 Aβ 沉积。然而，MSM 治疗改善了组织病理学损伤，改善了氧化应激、神经炎症和 AD 标志物的水平，并调节了 TREM-2/DAP-12/Syk 通路。我们的数据表明 MSM 提供针对 BPA 和 R 的神经保护作用；支持其在相关神经退行性疾病中的潜在应用。
更新日期：2020-09-12
中文翻译：
甲基磺酰甲烷对 BPA/γ 辐射诱导的大鼠神经退行性改变的调节作用：TREM-2/DAP-12/Syk 通路的影响
甲基磺酰甲烷 (MSM) 是一种有机硫化合物，具有许多健康益处。双酚 A (BPA) 和 γ 辐射 (R) 是人类在日常生活中接触的两种危险环境污染物。这项工作旨在揭示 MSM 在对抗 BPA 和 R 共同暴露引起的神经退行性疾病（阿尔茨海默病 (AD) 模拟神经毒性）中的调节作用。雌性大鼠被随机分为五组。一组为正常对照，其他四组接受亚急性 BPA 中毒和/或暴露于每周分次剂量的 R，持续 4 周，并且不治疗或同时接受 MSM 治疗。 BPA 和 R 共同暴露会诱发神经退行性疾病的典型特征，表现为氧化应激大幅升高、广泛的神经炎症（肿瘤坏死因子 -α 和白细胞介素 1β）、AD 标志物（淀粉样蛋白 -β (Aβ)、乙酰胆碱酯酶 (AchE) 活性升高）和 tau 磷酸化）以及在髓样细胞 2 (TREM-2)/12 kDa DNAX 激活蛋白 (DAP-12)/脾酪氨酸上表达的小胶质细胞促炎触发受体的上调海马激酶 (Syk) 通路及其下游靶标 (PLC-γ/DAG/p38-MAPK)。此外，皮层和海马的组织病理学检查显示神经退行性病变，并伴有海马中明显的 Aβ 沉积。然而，MSM 治疗改善了组织病理学损伤，改善了氧化应激、神经炎症和 AD 标志物的水平，并调节了 TREM-2/DAP-12/Syk 通路。我们的数据表明 MSM 提供针对 BPA 和 R 的神经保护作用；支持其在相关神经退行性疾病中的潜在应用。
京公网安备 11010802027423号