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The Alopecia Areata Consensus of Experts (ACE) study part II: Results of an international expert opinion on diagnosis and laboratory evaluation for alopecia areata
Journal of the American Academy of Dermatology ( IF 12.8 ) Pub Date : 2020-09-12 , DOI: 10.1016/j.jaad.2020.09.028
Nekma Meah 1 , Dmitri Wall 2 , Katherine York 3 , Bevin Bhoyrul 1 , Laita Bokhari 1 , Daniel Asz-Sigall 4 , Wilma F Bergfeld 5 , Regina C Betz 6 , Ulrike Blume-Peytavi 7 , Valerie Callender 8 , Vijaya Chitreddy 1 , Andrea Combalia 9 , George Cotsarelis 10 , Brittany Craiglow 11 , Jeff Donovan 12 , Samantha Eisman 1 , Paul Farrant 13 , Jack Green 14 , Ramon Grimalt 15 , Matthew Harries 16 , Maria Hordinsky 17 , Alan D Irvine 18 , Satoshi Itami 19 , Victoria Jolliffe 20 , Brett King 21 , Won-Soo Lee 22 , Amy McMichael 23 , Andrew Messenger 24 , Paradi Mirmirani 25 , Elise Olsen 26 , Seth J Orlow 27 , Bianca Maria Piraccini 28 , Adriana Rakowska 29 , Pascal Reygagne 30 , Janet L Roberts 31 , Lidia Rudnicka 29 , Jerry Shapiro 27 , Pooja Sharma 1 , Antonella Tosti 32 , Annika Vogt 7 , Martin Wade 33 , Leona Yip 34 , Abraham Zlotogorski 35 , Rodney D Sinclair 1
Affiliation  

Background

We previously reported the Alopecia Areata Consensus of Experts study, which presented results of an international expert opinion on treatments for alopecia areata.

Objective

To report the results of the Alopecia Areata Consensus of Experts international expert opinion on diagnosis and laboratory evaluation for alopecia areata.

Methods

Fifty hair experts from 5 continents were invited to participate in a 3-round Delphi process. Consensus threshold was set at greater than or equal to 66%.

Results

Of 148 questions, expert consensus was achieved in 82 (55%). Round 1 consensus was achieved in 10 of 148 questions (7%). Round 2 achieved consensus in 47 of 77 questions (61%). The final face-to-face achieved consensus in 25 of 32 questions (78%). Consensus was greatest for laboratory evaluation (12 of 14 questions [86%]), followed by diagnosis (11 of 14 questions [79%]) of alopecia areata. Overall, etiopathogenesis achieved the least category consensus (31 of 68 questions [46%]).

Limitations

The study had low representation from Africa, South America, and Asia.

Conclusion

There is expert consensus on aspects of epidemiology, etiopathogenesis, clinical features, diagnosis, laboratory evaluation, and prognostic indicators of alopecia areata. The study also highlights areas where future clinical research could be directed to address unresolved hypotheses in alopecia areata patient care.



中文翻译:

斑秃专家共识 (ACE) 研究第二部分:斑秃诊断和实验室评估的国际专家意见结果

背景

我们之前报道了斑秃专家共识研究,该研究展示了斑秃治疗的国际专家意见结果。

客观的

报告斑秃专家共识关于斑秃诊断和实验室评估的国际专家意见结果。

方法

来自五大洲的五十位头发专家受邀参加了3轮Delphi流程。共识阈值设置为大于或等于 66%。

结果

在 148 个问题中,82 个问题(55%)达成了专家共识。在 148 个问题中的 10 个问题 (7%) 中达成了第一轮共识。第 2 轮在 77 个问题中的 47 个问题(61%)中达成了共识。最后的面对面在 32 个问题中的 25 个问题(78%)中达成了共识。实验室评估的共识最高(14 个问题中的 12 个问题 [86%]),其次是斑秃的诊断(14 个问题中的 11 个问题 [79%])。总体而言,病因达成了最少的类别共识(68 个问题中的 31 个问题 [46%])。

限制

该研究在非洲、南美洲和亚洲的代表性较低。

结论

关于斑秃的流行病学、发病机制、临床特征、诊断、实验室评估和预后指标等方面有专家共识。该研究还强调了未来临床研究可以用于解决斑秃患者护理中尚未解决的假设的领域。

更新日期:2020-09-12
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