Envelope (E) protein is one of the structural viroporins (76–109 amino acids) present in the coronavirus. Sixteen sequentially different E-proteins were observed from a total of 4917 available complete genomes as on 18th June 2020 in the NCBI database. The missense mutations over the envelope protein across various coronaviruses of the β-genus were analyzed to know the immediate parental origin of the envelope protein of SARS-CoV2. The evolutionary origin is also endorsed by the phylogenetic analysis of the envelope proteins comparing sequence homology as well as amino acid conservations.

中文翻译：

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冠状病毒包膜蛋白的分子系统发育和错义突变。

包膜 (E) 蛋白是冠状病毒中存在的结构病毒孔蛋白（76-109 个氨基酸）之一。截至 2020 年 6 月 18 日，从 NCBI 数据库中总共 4917 个可用的完整基因组中观察到 16 个连续不同的E蛋白。分析了β属各种冠状病毒包膜蛋白的错义突变，以了解 SARS-CoV2 包膜蛋白的直接亲本起源。比较序列同源性和氨基酸保守性的包膜蛋白的系统发育分析也证实了进化起源。