Abstract Poly(lactide) (PLA) is a widely used biomaterial in many biomedical applications. However, it is inert and therefore lacks bioactivity, which is a major drawback in addressing tissue regeneration issues. This work aims to develop new implantable biomaterials composed of PLAs functionalized with bioactive peptides. For that purpose, we set up an original synthesis based on star-PLA bearing triethoxysilyl propyl groups (PLA-PTES) and bifunctional silylated peptides that react together via sol-gel process to create a bioactive network. We demonstrate that the molecular weight of the PLA and the quantity of peptide have a large influence on the crosslinking efficiency, the mechanical properties and the biodegradability of the resulting materials. The presence of peptide increases the crosslinking efficiency of the networks resulting in more rigid networks with stable mechanical properties up to 8 weeks. At last, the potential of this new type of hybrid biomaterials for soft tissue engineering was demonstrated through cells adhesion assays that showed a significant enhancement of fibroblasts adhesion.

中文翻译：

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星-聚（丙交酯）-肽杂化网络作为生物活性材料

摘要 聚丙交酯 (PLA) 是一种广泛用于许多生物医学应用的生物材料。然而，它是惰性的，因此缺乏生物活性，这是解决组织再生问题的主要缺点。这项工作旨在开发由具有生物活性肽功能化的 PLA 组成的新型可植入生物材料。为此，我们建立了基于带有三乙氧基甲硅烷基丙基 (PLA-PTES) 和双功能硅烷化肽的星形 PLA 的原始合成，这些肽通过溶胶-凝胶工艺共同反应以创建生物活性网络。我们证明了 PLA 的分子量和肽的数量对所得材料的交联效率、机械性能和生物降解性有很大影响。肽的存在提高了网络的交联效率，从而形成了更坚固的网络，并具有长达 8 周的稳定机械性能。最后，通过显示成纤维细胞粘附显着增强的细胞粘附测定证明了这种新型混合生物材料用于软组织工程的潜力。