The development of drug-resistant bacteria, as well as multidrug-resistant pathogens related to substantial mortality, is an important global health threat. The wide range of biological activities and the wealthy use of coumarin-containing drugs in the clinic have encouraged more and more interest in this class of heterocycles. Various coumarin-based antibiotic hybrids have been developed in the last decade and most of them exhibited potential antibacterial potency. This present review summarizes the current innovations of coumarin-based derivatives with potential antibacterial activities against a variety of Gram-negative and Gram-positive bacteria discussing various aspects of structure-activity relationship (SAR). The improved SAR will provide further insight into the rational improvement of coumarin hybrids with astounding strength against multidrug-resistant bacteria.

与大量死亡率相关的耐药细菌以及多药耐药病原体的发展是重要的全球健康威胁。临床上广泛的生物学活动和含香豆素类药物的大量使用，引起了人们对这类杂环的越来越多的兴趣。在过去的十年中，已经开发出了多种基于香豆素的抗生素杂种，其中大多数具有潜在的抗菌效力。这篇综述总结了基于香豆素的衍生物的最新创新，该衍生物对多种革兰氏阴性和革兰氏阳性细菌具有潜在的抗菌活性，并讨论了结构-活性关系（SAR）的各个方面。