Objective

The sources of iliac crest bone grafts are limited. Alternatives are evaluated due to the progress in biomaterial sciences. Synthetical hydroxyapatite (HA), ß-tricalcium phosphate (ß-TCP) or biphasic compounds, or even a mélange of HA and ß-TCP will replace bovine ceramics. The goal is maintenance of replica-based-bone formation (RBBF) for bone augmentation.

Methods

2 female and 2 male patients between 41 and 73 years with 5 sinus elevations were evaluated. Sinus elevations with lateral fenestration, trapezoidal-muco-periosteal flaps and filling with micro-chambered beads (1.5 mm) was performed. A porcine-collagenous membrane and the refixated flap covered the defect. A biopsy program over 20 months was confirm confirm the maintenance of the newly formed bone.

Results

A fast bone formation was pronounced. The biopsies revealed mature lamellar bone and full osseointegration of the ß-TCP implant. The biopsy after 20 months showed compact bone with osseointegration of minor rests of the ceramic implant. The defect revealed a mature bone stock already after 5 weeks.

Significance

The introduction of the replica-based-bone formation (RBBF) around micro-chambered beads will change the paradigm of bone augmentation. The next step of the ongoing study has to redefine the interval for implant insertion.

The clinical approach confirms the breakthrough to primary mature lamellar bone formation and will permit reduction of placement time for a dental implant.

中文翻译：

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通过基于副本的骨骼形成来增强骨骼。

目的

骨植骨的来源是有限的。由于生物材料科学的进步，对替代品进行了评估。合成羟基磷灰石（HA），β-磷酸三钙（ß-TCP）或双相化合物，甚至HA和ß-TCP的混杂物都将取代牛陶瓷。目标是维持基于复制的骨骼形成（RBBF）进行骨骼增强。

方法

评估2例女性和2例男性患者，年龄在41至73岁之间，鼻窦高度升高5次。进行侧窗开窗，梯形-粘膜-骨膜瓣并填充微腔珠（1.5 mm）来填充窦。猪胶原膜和固定的皮瓣覆盖了缺损。超过20个月的活检程序被确认可以确认新形成的骨的维护。

结果

快速骨形成明显。活检显示成熟的层状骨和ß-TCP植入物的完整骨整合。20个月后的活组织检查显示骨密实，并伴有陶瓷植入物的少量残留。缺损显示5周后骨骼已经成熟。

意义

在微腔珠周围引入基于复制的骨形成（RBBF）将改变骨骼增强的范例。正在进行的研究的下一步必须重新定义植入物的插入间隔。

临床方法证实了对主要成熟层状骨形成的突破，并将减少牙科植入物的放置时间。