Abstract This paper presents a method of preparing process maps for the bioethanol production process by continuous fermentation. The proposed method of process map construction is based on the nonlinear analysis of bioreactor steady states and the metabolic interpretation method of the steady state branches. The nonlinear analysis of bioreactor steady states was performed relative to the dilution rate and the mass recirculation coefficient. It revealed the presence of nonlinear phenomena in the system, such as Hopf bifurcation points and limit points. The use of the qualitative interpretation method of bifurcation diagrams allowed the detection of metabolic change points and multiple steady state areas in which the metabolic activity of biomass cells undergoes changes. Taking this information into account together with the determined gradient profile of bioethanol concentrations has made it possible to construct a process map with metabolic constraints.

中文翻译：

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通过连续发酵生产生物乙醇的具有代谢约束的工艺图

摘要 本文提出了一种制备连续发酵生物乙醇生产工艺流程图的方法。所提出的流程图构建方法基于生物反应器稳态的非线性分析和稳态分支的代谢解释方法。生物反应器稳态的非线性分析是相对于稀释率和质量再循环系数进行的。它揭示了系统中存在的非线性现象，如 Hopf 分岔点和极限点。使用分叉图的定性解释方法可以检测代谢变化点和生物质细胞代谢活动发生变化的多个稳态区域。