A lab-scale (0.03 m d_i, 0.4 m H) bubble column is investigated as a means of achieving low-temperature evaporation of process streams containing dissolved pharmaceutical APIs in batch and continuous modes. A thermodynamic model is developed from first principles which predicts the rate of evaporation of pure solvents, using a dry stream of air bubbles as the driving force for the mass transfer from a liquid to a gas phase. This model is validated experimentally, and it is demonstrated that saturation is achieved almost instantaneously between liquid and the gas, highlighting the efficiency and potential of this method. Maintaining the bubble flow in the homogeneous regime, various rates of solvent evaporation were achieved based on the solvent's characteristic volatility and fixed process variables. All modelling prediction rates of evaporation of pure solvents are within satisfactory errors of experimental measurements (<5% absolute). Batch experiments were performed with solutions of API and a reduction in predicted evaporation rate was observed. Based on experimental results from batch mode, an experimental method is shown to achieve controlled, continuous solution concentrations.

实验室规模（0.03 m d _i，0.4 m H）对鼓泡塔进行了研究，以实现以间歇和连续方式对包含溶解的药物API的工艺流进行低温蒸发的方法。热力学模型是从第一原理发展而来的，该原理使用干燥的气泡流作为从液体到气相的质量转移的驱动力，预测纯溶剂的蒸发速率。通过实验验证了该模型，并证明了在液体和气体之间几乎可以瞬间达到饱和，从而突出了该方法的效率和潜力。将气泡保持在均相状态，根据溶剂的特征挥发性和固定的工艺变量，可以实现各种溶剂蒸发速率。纯溶剂蒸发的所有建模预测速率都在令人满意的实验测量误差范围内（绝对值<5％）。使用API​​溶液进行批量实验，观察到预计的蒸发速率降低。基于批处理模式的实验结果，显示了一种实验方法可实现受控的连续溶液浓度。