Developing an ideal photothermal agent is one of the challenges for effective photothermal therapy (PTT). Herein, a green and simple yet versatile method is developed to construct a novel poly-(iron-dopamine coordination complexes) nanoparticles (P[Fe-DA]-NPs) based on polymerization and coordination synergistically by using Fe³⁺ ions and dopamine (DA) in aqueous solution, and simultaneously poly(vinylpyrrolidone) (PVP) is applied to improve dispersion stability. P[Fe-DA]-NPs can be laden into macrophages directly with no further purification required to target tumor tissue to perform cell-mediated strategy. P[Fe-DA]-laden macrophages as an ideal photothermal agent has the advantages of good biocompatibility, simple preparation process, high photothermal performance, and effective tumor targeting. Furthermore, the P[Fe-DA]-laden macrophages possess excellent photoacoustic imaging (PAI) capacity for guiding the precise PTT. The results show that the tumors are significantly suppressed after PTT with the help of the accurate PAI diagnosis. This cell-mediated strategy may be the most promising avenue for the future clinical cancer therapy.

开发理想的光热剂是有效光热疗法（PTT）的挑战之一。在本文中，开发了一种绿色简单而通用的方法，通过使用Fe ³⁺协同协同作用，构建了一种新型的聚（铁-多巴胺配位络合物）纳米粒子（P [Fe-DA] -NPs）。离子和水溶液中的多巴胺（DA），并同时使用聚乙烯吡咯烷酮（PVP）来提高分散稳定性。P [Fe-DA] -NPs可以直接装载到巨噬细胞中，而无需进一步纯化即可靶向肿瘤组织以执行细胞介导的策略。载有P [Fe-DA]的巨噬细胞作为理想的光热剂，具有生物相容性好，制备工艺简单，光热性能高，有效靶向肿瘤的优点。此外，富含P [Fe-DA]的巨噬细胞具有出色的光声成像（PAI）能力，可用于指导精确的PTT。结果表明，借助精确的PAI诊断，PTT后可显着抑制肿瘤。这种细胞介导的策略可能是未来临床癌症治疗的最有希望的途径。