Most fish species are susceptible to red-spotted grouper nervous necrosis virus (RGNNV) which causes viral encephalopathy and retinopathy leading to huge financial losses in the aquaculture farming industry for decades. A knowledge of RGNNV replication and the host response in depth is warranted to understand the host-virus interaction and to develop an effective approach to inhibit this virus. This study therefore aimed to investigate the expression of selected immune and stress-related genes of the E-11 clonal cell line upon RGNNV infection. The results showed significant upregulation of , and transcripts at 48 h post infection, while the transcript abundance of , , showed increases which did not reach significance and showed no change in expression in response to infection. This study highlights the involvement of , and during RGNNV infection of E-11 cells which provides a clearer understanding of the pathogenic mechanism of the disease.

中文翻译：

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E-11细胞系选定基因响应红斑石斑鱼神经坏死病毒感染的表达谱


大多数鱼类都容易感染红斑石斑鱼神经坏死病毒（RGNNV），该病毒会导致病毒性脑病和视网膜病，导致水产养殖业数十年来遭受巨大经济损失。需要深入了解 RGNNV 复制和宿主反应，才能了解宿主与病毒的相互作用并开发抑制该病毒的有效方法。因此，本研究旨在研究 E-11 克隆细胞系在 RGNNV 感染后选定的免疫和应激相关基因的表达。结果显示， 、 和 转录本在感染后 48 小时显着上调，而 、 、 转录本丰度则有所增加，但未达到显着水平，且感染后的表达没有变化。这项研究强调了 RGNNV 感染 E-11 细胞期间 和 的参与，这为该疾病的致病机制提供了更清晰的了解。