Clinicopathologic correlations of segmental villous avascularity and other histological lesions of segmental fetal vascular malperfusion (SFVM) were analyzed retrospectively to determine whether lesions of various durations reflect different etiopathogeneses. The frequencies of 25 independent clinical and 43 placental phenotypes were statistically compared by ANOVA or Chi-square among 3 groups containing a total of 378 placentas with SFVM: group 1 contained 44 cases of recent SFVM (endothelial fragmentation, villous hypovascularity by CD34 immunostain, and/or stromal vascular karyorrhexis); group 2 contained 264 cases of established SFVM (clusters of avascular villi); and group 3 contained 70 cases of remote SFVM (villous mineralization). Statistically significant differences among the three study groups (p Bonferroni < 0.002) were found in four clinical variables (gestational age, frequencies of macerated stillbirth, induction of labor, and cesarean section) and in five placental variables (frequencies of fetal vascular ectasia, stem vessel luminal vascular abnormalities, diffusely increased extracellular matrix in chorionic villi, chorionic disk extravillous trophoblast microcysts, and excessive extravillous trophoblasts in the chorionic disc). In summary, the absence of statistically significant differences between the study groups regarding the most common causes of SFVM (hypertensive conditions of pregnancy, diabetes mellitus, fetal anomalies, and clinical and pathological features of umbilical cord compromise) is evidence that the three types of SFVM reflect temporal heterogeneity rather than etiopathogenesis. This evidence can be used to date the onset of fetal vascular malperfusion before delivery or stillbirth. The coexistence of different SVFM lesions of various durations indicates ongoing or repeat occurrences of FVM rather than single episodes.

回顾性分析节段性绒毛无血管性和节段性胎儿血管灌注不良（SFVM）的其他组织学病变的临床病理相关性，以确定不同持续时间的病变是否反映了不同的病因。通过ANOVA或卡方检验对3组共378个SFVM胎盘的SFVM进行统计学比较，比较了25种独立的临床表型和43种胎盘表型的频率：第1组包含44例近期的SFVM（内皮碎裂，CD34免疫染色的绒毛性低血运和/或间质性血管核淋巴结炎）；第2组包含264例已建立的SFVM（无绒毛簇）；第3组包含70例远程SFVM（不良矿化）病例。三个研究组之间的统计学差异（pBonferroni <0.002）存在于四个临床变量（胎龄，浸渍死产的频率，引产和剖宫产）和五个胎盘变量（胎儿血管扩张的频率，干血管腔血管异常，弥漫性增加的细胞外基质）中绒毛膜绒毛，绒毛膜盘外滋养层微囊和绒毛膜盘内多余的绒毛外滋养层）。总之，研究组之间关于SFVM的最常见原因（妊娠高血压状况，糖尿病，胎儿异常以及脐带受损的临床和病理特征）在统计学上没有显着差异，这证明了SFVM的三种类型反映时间异质性而不是病因。该证据可用于在分娩或死胎之前确定胎儿血管灌注不良的发生日期。不同持续时间的不同SVFM病变的共存表明FVM正在进行或重复出现，而不是单发。