Noise has always been an important environmental factor that induces health problems in the general population. Due to ever increasing noise pollution, humans are facing multiple auditory and non-auditory problems including neuropsychiatric disorders. In modern day life it is impossible to avoid noise due to the rapid industrialization of society. Continuous exposure to noise stress creates a disturbance in brain function which may lead to memory disorder. Therefore, it is necessary to find preventive measures to reduce the deleterious effects of noise exposure. Supplementation of taurine, a semi essential amino acid, is reported to alleviate psychiatric disorders. In this study noise-exposed (100 db; 3 h daily for 15 days) rats were supplemented with taurine at a dose of 100 mg/kg for 15 days. Spatial and recognition memory was assessed using the Morris water maze and novel object recognition task, respectively. Results of this study showed a reversal of noise-induced memory impairment in rats. The derangements of catecholaminergic and serotonergic levels in the hippocampus and altered brain antioxidant enzyme activity due to noise exposure were also restored by taurine administration. This study highlights the importance of taurine supplementation to mitigate noise-induced impaired memory via normalizing the neurochemical functions and reducing oxidative stress in rat brain.

噪音一直是引起普通人群健康问题的重要环境因素。由于不断增加的噪音污染，人类面临着多种听觉和非听觉问题，包括神经精神疾病。在现代生活中，由于社会的快速工业化，无法避免噪音。持续暴露于噪音压力会导致大脑功能紊乱，从而导致记忆障碍。因此，有必要寻找预防措施来减少噪声暴露的有害影响。据报道，补充牛磺酸（一种半必需氨基酸）可缓解精神疾病。在这项研究中，暴露于噪音（100 分贝；每天 3 小时，持续 15 天）的大鼠以 100 毫克/千克的剂量补充牛磺酸，持续 15 天。分别使用莫里斯水迷宫和新物体识别任务评估空间和识别记忆。这项研究的结果表明，噪音引起的大鼠记忆障碍逆转。海马中儿茶酚胺能和血清素能水平的紊乱以及由于噪音暴露引起的大脑抗氧化酶活性的改变也通过牛磺酸恢复。这项研究强调了补充牛磺酸通过使神经化学功能正常化和减少大鼠大脑中的氧化应激来减轻噪音引起的记忆障碍的重要性。海马中儿茶酚胺能和血清素能水平的紊乱以及由于噪音暴露引起的大脑抗氧化酶活性的改变也通过牛磺酸恢复。这项研究强调了补充牛磺酸通过使神经化学功能正常化和减少大鼠大脑中的氧化应激来减轻噪音引起的记忆障碍的重要性。海马中儿茶酚胺能和血清素能水平的紊乱以及由于噪音暴露引起的大脑抗氧化酶活性的改变也通过牛磺酸恢复。这项研究强调了补充牛磺酸通过使神经化学功能正常化和减少大鼠大脑中的氧化应激来减轻噪音引起的记忆障碍的重要性。