COVID-19 caused by the SARS-CoV-2 outbreak quickly has turned into a pandemic. However, no specific antiviral agent is yet available. In this communication, we aimed to evaluate the significance of CD147 protein and the potential protective effect of melatonin that is mediated by this protein in COVID-19. CD147 is a glycoprotein that is responsible for the cytokine storm in the lungs through the mediation of viral invasion. Melatonin use previously was shown to reduce cardiac damage by blocking the CD147 activity. Hence, melatonin, a safe drug, may prevent severe symptoms, reduce symptom severity and the adverse effects of the other antiviral drugs in COVID-19 patients. In conclusion, the use of melatonin, which is reduced in the elderly and immune-compromised patients, should be considered as an adjuvant through its CD147 suppressor and immunomodulatory effect.

由SARS-CoV-2爆发引起的COVID-19迅速变成了大流行病。但是，尚无特定的抗病毒剂。在本交流中，我们旨在评估CD147蛋白的重要性以及褪黑激素在COVID-19中介导的褪黑激素的潜在保护作用。CD147是一种糖蛋白，可通过介导病毒入侵来引起肺中的细胞因子风暴。以前使用褪黑素可通过阻断CD147活性来减少心脏损害。因此，褪黑激素是一种安全的药物，可以预防严重的症状，减轻症状的严重程度以及其他抗病毒药物对COVID-19患者的不良影响。总之，褪黑激素的使用在老年人和免疫功能低下的患者中减少了，