In this review we summarize the cellular and molecular events of inflammation induced epithelial-to-mesenchymal (EMT) and mesothelial-to-macrophage transition (MET) during regeneration. Since the receptor transmits the environmental stimulus, downregulating or upregulating the process on an epigenetic level, the intracellular localization of receptors (signaling organelles: early endosomes or lysosomal degradation: late endosomes) plays a crucial role in the signaling events regulating inflammation and regeneration. Therefore, we focused on the internalization of the receptors as well as the intracellular compartmentalization of signaling molecules during EMT and MET. The review draws the reader’s attention to the plasticity of mesothelial cells and supports the idea that during inflammation an ambient macrophage population might derive from mesothelial cells.

在这篇综述中，我们总结了再生过程中炎症诱导的上皮-间质 (EMT) 和间皮-巨噬细胞转化 (MET) 的细胞和分子事件。由于受体传递环境刺激，在表观遗传水平上下调或上调该过程，因此受体的细胞内定位（信号细胞器：早期内体或溶酶体降解：晚期内体）在调节炎症和再生的信号事件中起着至关重要的作用。因此，我们专注于 EMT 和 MET 期间受体的内化以及信号分子的细胞内区室化。