Imaging of small laboratory animals in clinical MRI scanners is feasible but challenging. Compared with dedicated preclinical systems, clinical scanners have relatively low B₀ field (1.5–3.0 T) and gradient strength (40–60 mT/m). This work explored the use of wireless inductively coupled coils (ICCs) combined with appropriate pulse sequence parameters to overcome these two drawbacks, with a special emphasis on the optimization of the coil passive detuning circuit for this application. A Bengal rose photothrombotic stroke model was used to induce cortical infarction in rats and mice. Animals were imaged in a 3T scanner using T2 and T1-weighted sequences. In all animals, the ICCs allowed acquisition of high-quality images of the infarcted brain at acute and chronic stages. Images obtained with the ICCs showed a substantial increase in SNR compared to clinical coils (by factors of 6 in the rat brain and 16–17 in the mouse brain), and the absence of wires made the animal preparation workflow straightforward.

在临床 MRI 扫描仪中对小型实验室动物进行成像是可行的，但具有挑战性。与专用的临床前系统相比，临床扫描仪的 B ₀相对较低场 (1.5–3.0 T) 和梯度强度 (40–60 mT/m)。这项工作探索了使用无线电感耦合线圈 (ICC) 结合适当的脉冲序列参数来克服这两个缺点，并特别强调了针对该应用的线圈无源失谐电路的优化。孟加拉玫瑰光血栓形成中风模型用于诱导大鼠和小鼠的皮质梗塞。使用 T2 和 T1 加权序列在 3T 扫描仪中对动物进行成像。在所有动物中，ICC 允许在急性和慢性阶段获取梗塞大脑的高质量图像。与临床线圈相比，使用 ICC 获得的图像显示 SNR 显着增加（大鼠大脑中的因子为 6，小鼠大脑中的因子为 16-17），并且没有电线使动物准备工作流程变得简单。