Porphyromonas gingivalis is a Gram-negative anaerobic periodontal microorganism strongly associated with tissue destructive processes in human periodontitis. Following oral infection with P. gingivalis, the periodontal bone loss in mice is reported to require engagement of Toll-like receptor 2 (TLR2). Serine-glycine lipodipeptide or glycine aminolipid classes of P. gingivalis engage human and mouse TLR2 but a novel lipid class reported here is considerably more potent in engaging TLR2 and the heterodimer receptor TLR2/TLR6. The novel lipid class, termed Lipid 1256, consists of a diacylated phosphoglycerol moiety linked to a serine-glycine lipodipeptide, previously termed Lipid 654. Lipid 1256 is approximately 50-fold more potent in engaging TLR2 than the previously reported serine-glycine lipid classes. Lipid 1256 also stimulates cytokine secretory responses from peripheral blood monocytes and is recovered in selected oral and intestinal Bacteroidetes organisms. Therefore, these findings suggest that Lipid 1256 may be a microbial TLR2 ligand relevant to chronic periodontitis in humans.

中文翻译：

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牙龈卟啉单胞菌的一种新型磷酸甘油丝氨酸-甘氨酸脂二肽是 TLR2 配体。


牙龈卟啉单胞菌是一种革兰氏阴性厌氧牙周微生物，与人类牙周炎的组织破坏过程密切相关。据报道，口腔感染牙龈卟啉单胞菌后，小鼠牙周骨质流失需要 Toll 样受体 2 (TLR2) 的参与。牙龈卟啉单胞菌的丝氨酸-甘氨酸脂二肽或甘氨酸氨基脂质类与人和小鼠 TLR2 结合，但本文报道的新型脂质类在与 TLR2 和异二聚体受体 TLR2/TLR6 结合方面要有效得多。这种新型脂质类称为“脂质 1256”，由与丝氨酸-甘氨酸脂二肽（以前称为“脂质 654”）连接的二酰化磷酸甘油部分组成。脂质 1256 与 TLR2 结合的能力比先前报道的丝氨酸-甘氨酸脂质类强约 50 倍。 Lipid 1256 还可刺激外周血单核细胞的细胞因子分泌反应，并在选定的口腔和肠道拟杆菌中回收。因此，这些发现表明Lipid 1256可能是与人类慢性牙周炎相关的微生物TLR2配体。