Abstract The use of electronic cigarettes increases as a supposedly healthier form of nicotine consumption, but safety of vaping remains uncertain. In this study, we assessed whether the use of electronic cigarettes increases the risk of infertility in male rats. Malformations of sperm morphology were more frequent in nicotine-exposed groups than in the control group. Vacuolization of seminiferous epithelium, reduction of spermatogenesis, increased apoptosis of spermatogonia and spermatocytes, and acceleration of degeneration of testes were observed. The male reproductive organs are slightly less affected by vaping than by smoking. Nevertheless, in consequence both may lead to the reduction of fertility.

中文翻译：

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暴露于香烟烟雾或电子烟蒸气的雄性大鼠生殖系统的组织学变化

摘要 电子烟的使用作为一种据称更健康的尼古丁消费形式而增加，但电子烟的安全性仍不确定。在这项研究中，我们评估了电子烟的使用是否会增加雄性大鼠的不孕风险。与对照组相比，尼古丁暴露组的精子形态畸形更常见。观察到生精上皮空泡化、精子发生减少、精原细胞和精母细胞凋亡增加以及睾丸退化加速。与吸烟相比，电子烟对男性生殖器官的影响略小。然而，结果两者都可能导致生育率的降低。