Amide C−N bonds are thermodynamically stable and their fission, such as by hydrolysis and alcoholysis, is considered a long‐challenging organic reaction. In general, stoichiometric chemical transformations of amides into the corresponding esters and acids require harsh conditions, such as strong acids/bases at a high reaction temperature. Accordingly, the development of catalytic reactions that cleave not only primary and secondary amides, but also tertiary amides in mild conditions, is in high demand. Herein, we surveyed typical stoichiometric transformations of amides, and highlight our recent achievements in the catalytic esterification of amides using scandium, manganese, and zinc catalysts, together with some recent catalyst systems using late‐transition metal reported by other groups.

中文翻译：

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酰胺C-N键的催化裂解：用于酰胺化的dium，锰和锌催化剂

酰胺CN键具有热力学稳定性，其裂变（例如通过水解和醇解作用）被认为是一个具有挑战性的有机反应。通常，酰胺向相应的酯和酸的化学计量化学转化需要苛刻的条件，例如在高反应温度下的强酸/碱。因此，迫切需要开发在温和条件下不仅裂解伯酰胺和仲酰胺，而且裂解叔酰胺的催化反应。本文中，我们调查了酰胺的典型化学计量转化，并重点介绍了我们在使用scan，锰和锌催化剂进行酰胺催化酯化方面的最新成就，以及一些其他团体最近报告的使用后期过渡金属的催化剂体系。