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1-[Bis(dimethylamino)methylene]-1 H -1,2,3-triazolo[4,5- b ]pyridinium 3-Oxide Hexafluorophosphate (HATU)/Hydroxybenzotriazole (HOBT)-based One-Pot Cyclization of N -Substituted 2-Arylbenzimidazole Derivatives
Russian Journal of Organic Chemistry ( IF 0.8 ) Pub Date : 2020-06-26 , DOI: 10.1134/s107042802005019x Y. T. Duan , T. H. Parmar , C. B. Sangani , A. S. Shah , R. K. Ameta
中文翻译:
1- [双(二甲基氨基)亚甲基] -1 H -1,2,3-三唑并[4,5-b] 3-氧合吡啶鎓六氟磷酸盐(HATU)/羟基苯并三唑(HOBT)基N取代基的一锅法2-芳基苯并咪唑衍生物
更新日期:2020-06-26
Russian Journal of Organic Chemistry ( IF 0.8 ) Pub Date : 2020-06-26 , DOI: 10.1134/s107042802005019x Y. T. Duan , T. H. Parmar , C. B. Sangani , A. S. Shah , R. K. Ameta
Abstract
A simple one-pot synthesis of N-substituted benzimidazoles from aromatic carboxylic acids and aromatic 1,2-diamines in the presence of 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxide hexafluorophosphate/hydroxybenzotriazole (HATU/HOBT) and N,N-diisopropylethylamine in DMF at 100°C, featuring good to excellent yields and easy workup, is developed. The protocol can be scaled to gram quantities, and no chromatographic purification is required.中文翻译:
1- [双(二甲基氨基)亚甲基] -1 H -1,2,3-三唑并[4,5-b] 3-氧合吡啶鎓六氟磷酸盐(HATU)/羟基苯并三唑(HOBT)基N取代基的一锅法2-芳基苯并咪唑衍生物