Abstract

An ecofriendly, simple, and efficient one-pot protocol has been developed for the synthesis of 1,2,4,5-tetrasubstituted imidazoles by the reaction of benzil, aryl aldehydes, aliphatic or aromatic amines, and ammonium acetate, catalyzed by the acidic halogen-free ionic liquid [bmim]HSO₄ under solvent-free conditions. The advantages of the proposed protocol include high yields, short reaction time, operational simplicity, and recyclability of the catalyst. Eight previously unknown tetrasubstituted imidazoles were synthesized, among which those bearing a cyclopropyl substituent on N¹ can be considered as potential mutant isocitrate dehydrogenase 1 (IDH1) inhibitors.

中文翻译：

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[Bmim] HSO 4催化合成四取代的咪唑作为潜在的突变体异柠檬酸脱氢酶1抑制剂

摘要

已开发出一种环保，简单且有效的一锅操作规程，用于通过苯甲酰，芳基醛，脂肪族或芳香族胺与乙酸铵的乙酸催化反应合成1,2,4,5-四取代的咪唑在无溶剂条件下的无卤素离子液体[bmim] HSO ₄。所提出的方案的优点包括高产率，短反应时间，操作简单和催化剂的可回收性。合成了八种先前未知的四取代的咪唑，其中在N ¹上带有环丙基取代基的那些可被视为潜在的突变异柠檬酸脱氢酶1（IDH1）抑制剂。