Abstract

A series of novel 5-(1,2,3-triazolylmethylsulfanyl)tetrazole derivatives were synthesized by the click reaction from 1-phenyl-5-(prop-2-yn-1-ylsulfanyl)-1H-tetrazole and the corresponding azide. The reaction optimization results showed that higher yields are obtained using CuSO₄ and sodium ascorbate in DMF–water (2:1). The product structures were established on the basis of various spectral data, and their evaluation for antimicrobial activity showed moderate to good results compared to standard drugs.

中文翻译：

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5-{[（（1-Aryl-1 H -1,2,3-triazol-4-yl）methyl]硫基} -1-苯基-1 H-四唑的合成

摘要

通过1-苯-5-（prop-2-yn-1-ylsulfanyl）-1 H-四唑与相应的叠氮化物的点击反应合成了一系列新型的5-（1,2,3-三唑基甲基硫烷基）四唑衍生物。反应优化结果表明，使用CuSO ₄和抗坏血酸钠在DMF-水中（2：1）可获得更高的收率。产品结构是根据各种光谱数据建立的，与标准药物相比，其抗菌活性评估显示出中等至良好的结果。