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Synthesis and Anticancer Activity of 1,3,4-Oxadiazole-oxazolo[4,5- b ]pyridine Derivatives
Russian Journal of General Chemistry ( IF 0.9 ) Pub Date : 2020-08-10 , DOI: 10.1134/s107036322007021x
Suresh Babu Kokkiligadda , Sivanadh Musunuri , Bhimcharan Maiti , M. V. Basaveswara Rao , Gattu Sridhar

Abstract

A number of 1,3,4-oxadiazole incorporated oxazolo[4,5-b]pyridine derivatives has been synthesized, characterized and tested for anticancer activity against four human cancer cell lines including breast cancer (MCF-7), lung cancer (A549), colon cancer (Colo-205), and ovarian cancer (A2780) using etoposide as a standard drug. All products demonstrate good anticancer activity, several compounds can be considered as promising anticancer agents.


中文翻译:

1,3,4-恶二唑-恶唑并[4,5-b]吡啶衍生物的合成及抗癌活性

摘要

已经合成,结合了许多1,3,4-恶二唑的恶唑并[4,5- b ]吡啶衍生物,并针对包括乳腺癌(MCF-7),肺癌(A549)在内的四种人类癌细胞系测试了抗癌活性),结肠癌(Colo-205)和卵巢癌(A2780)(使用依托泊苷作为标准药物)。所有产品均显示出良好的抗癌活性,几种化合物可被视为有前途的抗癌剂。
更新日期:2020-08-10
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