Abstract

A number of 1,3,4-oxadiazole incorporated oxazolo[4,5-b]pyridine derivatives has been synthesized, characterized and tested for anticancer activity against four human cancer cell lines including breast cancer (MCF-7), lung cancer (A549), colon cancer (Colo-205), and ovarian cancer (A2780) using etoposide as a standard drug. All products demonstrate good anticancer activity, several compounds can be considered as promising anticancer agents.

中文翻译：

---

1,3,4-恶二唑-恶唑并[4,5-b]吡啶衍生物的合成及抗癌活性

摘要

已经合成，结合了许多1,3,4-恶二唑的恶唑并[4,5- b ]吡啶衍生物，并针对包括乳腺癌（MCF-7），肺癌（A549）在内的四种人类癌细胞系测试了抗癌活性），结肠癌（Colo-205）和卵巢癌（A2780）（使用依托泊苷作为标准药物）。所有产品均显示出良好的抗癌活性，几种化合物可被视为有前途的抗癌剂。