To raise the efficacy and the selectivity of known medicinal substances (MS), methods have recently been developed to create systems for their directed transport in the body using various carriers. The problem of decreasing the toxicity and increasing the selectivity of antitumor MSs is particularly relevant. In recent years, studies are underway for the development of conjugates of MSs and the natural polymers, in particular, the non-starch polysaccharides, many of which manifest antitumor and immunomodulatory properties. Owing to the unique combination of physicochemical and biological properties, arabinogalactan from larch wood (AG) is one of the most promising tools for the development of complex preparations with elevated bioavailability and reduced toxicity. The aim of the present work is to obtain mechanocomposites of cyclophosphamide (CPA) with the initial arabinogalactan (molecular mass 16 645 Da) and its fragments (molecular mass 8380 Da) and to study their physicochemical properties. According to IR and 13С, 15N and 31Р NMR spectroscopy, long-term mechanochemical treatment does not lead to a change in chemical composition of CPA molecules, only the formation of hydrogen bonds NH···OH is observed. The data on X-ray analysis, IR and multinuclear NMR spectroscopy show that, with a weight ratio of 1 : 5 and 1 : 10, disordering of CPA crystallographic structure and its molecular dispersion without chemical interaction of the components occur in the matrix of the polysaccharide with mechanical treatment of mixtures of CPA–AG over 4–12 hours.

中文翻译：

---

阿拉伯半乳聚糖与环磷酰胺机械复合物的合成及理化性质研究

为了提高已知药用物质 (MS) 的功效和选择性，最近开发了一些方法来创建使用各种载体在体内进行定向运输的系统。降低抗肿瘤 MS 的毒性和增加选择性的问题尤其重要。近年来，正在研究开发 MS 和天然聚合物的结合物，特别是非淀粉多糖，其中许多表现出抗肿瘤和免疫调节特性。由于物理化学和生物学特性的独特组合，落叶松木 (AG) 中的阿拉伯半乳聚糖是开发具有提高生物利用度和降低毒性的复杂制剂的最有前途的工具之一。本工作的目的是获得环磷酰胺 (CPA) 与初始阿拉伯半乳聚糖（分子量 16 645 Da）及其片段（分子量 8380 Da）的机械复合材料，并研究它们的理化性质。根据 IR 和 13С、15N 和 31Р NMR 光谱，长期机械化学处理不会导致 CPA 分子的化学成分发生变化，仅观察到氢键 NH···OH 的形成。X射线分析、红外光谱和多核核磁共振谱数据表明，在重量比为1:5和1:10的情况下，CPA晶体结构的无序及其分子分散发生在无组分化学相互作用的情况下。多糖对 CPA-AG 混合物进行机械处理 4-12 小时。