Abstract In this study, polycaprolactone (PCL) and polycaprolactone/fluoride substituted-hydroxyapatite (PCL/FHA) nanocomposite coatings at different composition (10, 20 and 30 wt.% of FHA) are deposited on alkali-treated Ti6Al4V substrate via in-situ sol-gel method to improve its corrosion behavior and in vitro bioactivity. The PCL and PCL/FHA nanocomposite coatings are characterized by scanning electron microscopy (SEM) equipped with X-ray energy dispersive spectrometer (EDS), X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR). The in vitro bioactivity and corrosion behavior of the coatings are also investigated to show their potential application for dental implants. The results indicate that the in-situ sol-gel process is capable of forming compact and crack-free coatings with a homogeneous dispersion of FHA as a ceramic phase in the polymeric matrix. By increasing the FHA content, the hydrophilicity, adhesion strength and surface roughness were increased. Furthermore, in vitro bioactivity of the PCL/FHA nanocomposite coatings was improved by increasing the FHA content and the incubation time in simulated body fluid (SBF). The corrosion resistance of the PCL/10 wt.% FHA coatings considerably increased as compared to the pure PCL and PCL/FHA coatings with 20 and 30 wt.% of FHA. Additionally, the MTT assay confirmed that the coatings have no considerable cytotoxicity effect and PCL/20 wt.% FHA coating promoted the proliferation and spreading of MG63 cells. Indeed, the results showed that the PCL/FHA nanocomposite coatings on alkali-treated Ti6Al4V substrate may be a promising candidate for dental implant applications.

中文翻译：

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聚己内酯/氟化物取代羟基磷灰石（PCL/FHA）纳米复合涂层通过原位溶胶-凝胶工艺制备，用于牙种植体应用

摘要 在本研究中，不同成分（10、20 和 30 wt.% FHA）的聚己内酯 (PCL) 和聚己内酯/氟化物取代羟基磷灰石 (PCL/FHA) 纳米复合涂层通过原位沉积在碱处理的 Ti6Al4V 基材上。溶胶-凝胶法改善其腐蚀行为和体外生物活性。PCL 和 PCL/FHA 纳米复合涂层通过配备 X 射线能量色散光谱仪 (EDS)、X 射线衍射 (XRD) 和傅里叶变换红外光谱 (FTIR) 的扫描电子显微镜 (SEM) 进行表征。还研究了涂层的体外生物活性和腐蚀行为，以显示其在牙科植入物中的潜在应用。结果表明，原位溶胶-凝胶工艺能够形成致密且无裂纹的涂层，其中 FHA 作为陶瓷相均匀分散在聚合物基体中。通过增加 FHA 含量，亲水性、粘附强度和表面粗糙度增加。此外，PCL/FHA 纳米复合涂层的体外生物活性通过增加 FHA 含量和在模拟体液 (SBF) 中的孵育时间得到改善。与具有 20 和 30 重量％ FHA 的纯 PCL 和 PCL/FHA 涂层相比，PCL/10 重量％ FHA 涂层的耐腐蚀性能显着提高。此外，MTT 测定证实涂层没有显着的细胞毒性作用，PCL/20 wt.% FHA 涂层促进了 MG63 细胞的增殖和扩散。确实，