A number of strontium-based iron oxides are available for the industrial use. Among them, strontium hexaferrite cobalt iron oxide (Sr₂Co₂Fe₁₂O₂₂) is preferred over others due to its better magnetic and electrical properties than others. This material is also extensively used for the absorption of microwave radiations. This study was conducted to account for the synthesis and characterization of Sr₂Co₂Fe₁₂O₂₂ nanoparticles and to report their biocompatibility in albino mice. Nanoparticles were synthesised by normal microemulsion, XRD analysis confirmed the single and scanning electron microscopy (SEM) revealed average particle size ranged between 30 and 50 nm. Nine-week-old male mice were intraperitoneally administered with 50 mg/mL of solvent/kg body weight of strontium hexaferrite cobalt iron oxide nanoparticles for 22 days. Control group was maintained in parallel. A series of neurological tests (rota rod, light and dark box, open field and Morris water maze) were conducted in both groups. Blood samples were collected from direct cardiac puncture, and parameters of complete blood count, serum biochemical parameters and antioxidant were determined in liver and brain tissues of all subjects. Analysis of result revealed that all studied neurological test performances varied nonsignificantly (P > 0.05) between the two treatments except clockwise rotations during open field test that were significantly reduced (P = 0.05) in Strontium hexaferrite Cobalt Iron Oxide nanoparticle-treated male albino mice than in the control group. All studied complete blood count and serum parameters varied nonsignificantly (P > 0.05) between two treatments. It was observed that superoxide dismutase concentration was significantly higher (P = 0.05) in the liver of nanoparticle-treated male mice. In conclusion, we are reporting that applied dose of strontium hexaferrite cobalt iron oxide nanoparticles is affecting the exploratory behaviour and antioxidant metabolites of male albino mice.

许多锶基氧化铁可用于工业用途。其中，由于六价铁酸锶钴铁氧化物（Sr ₂ Co ₂ Fe ₁₂ O ₂₂）的磁性能和电性能比其他更好，因此优选。这种材料也被广泛用于吸收微波辐射。进行这项研究是为了说明Sr ₂ Co ₂ Fe ₁₂ O ₂₂的合成和表征纳米颗粒，并报告其在白化病小鼠中的生物相容性。纳米粒子是通过常规微乳液合成的，XRD分析证实单次扫描电子显微镜（SEM）揭示了平均粒径在30至50 nm之间。九周龄的雄性小鼠腹膜内施用50 mg / mL溶剂/ kg体重的六锶铁氧体钴铁氧化物纳米颗粒，持续22天。对照组保持平行。两组均进行了一系列的神经系统测试（旋转棒，明暗盒，野外和莫里斯水迷宫）。通过直接心脏穿刺采集血样，并测定所有受试者肝脏和脑组织的全血细胞计数，血清生化参数和抗氧化剂。 两种处理之间的差异（P > 0.05），在开放视野测试期间顺时针旋转除外， 六氧化锶铁氧体钴铁氧化物纳米粒子治疗的雄性白化病小鼠比对照组明显降低（P = 0.05）。 在两种治疗之间，所有研究的全血细胞计数和血清参数变化均无统计学意义（P > 0.05）。观察到 纳米颗粒处理的雄性小鼠肝脏中超氧化物歧化酶的浓度明显更高（P = 0.05）。总而言之，我们报道了六锶铁氧体钴铁氧化物纳米粒子的使用剂量正在影响雄性白化病小鼠的探索行为和抗氧化代谢产物。