Abstract A V-shaped ion funnel (IF) drift tube was developed for proton transfer reaction mass spectrometry (PTR-MS). The ion transmissions were characterized at variable radio frequency voltages and frequencies to obtain optimized conditions while considering the effects of radial-focusing, reaction rate, and collision-induced dissociation. The improvements in sensitivity for common compounds were experimentally obtained and ranges from 2 to 22 times depending on the analyte. The product ions distributions were also studied for V-shaped IF PTR-MS. Together with the literature reports for U-shaped IF PTR-MS, a valuable and comprehensive reference is provided for future optimization of IF PTR-MS and other mass spectrometers.

中文翻译：

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V型离子漏斗质子转移反应质谱

摘要 研制了一种用于质子转移反应质谱（PTR-MS）的V形离子漏斗（IF）漂移管。离子传输在可变射频电压和频率下进行表征，以获得优化条件，同时考虑径向聚焦、反应速率和碰撞诱导解离的影响。常见化合物的灵敏度提高是通过实验获得的，范围从 2 到 22 倍，具体取决于分析物。还研究了 V 形 IF PTR-MS 的产物离子分布。结合U型中频PTR-MS的文献报道，为未来中频PTR-MS等质谱仪的优化提供了有价值的综合参考。