Abstract Ai pian, derived from Blumea balsamifera (L.) DC. has various medicinal effects and a complex composition. The goal of this study was to analyze the chemical composition of Ai pian by using samples from different regions to explore differences between the chemical composition and its blood composition from treated mice to clarify whether its efficacy is related to synergism of multiple components to provide references for rational quality control. Gas chromatography – mass spectrometry (GC-MS) was used to determine and compare chemical compositions of blank and Ai pian containing serum of mice after 30 min of oral administration of Ai pian of seven batches from Zhenfeng, Wangmo and Luodian Counties; Guizhou Province; and Tian’e County; and Guangxi Province. Sixteen to twenty-two compounds of Ai pian were identified, with fourteen common compounds including L-borneol, L-camphor, borneol acetate, L-linalool, α-gurjunene, and 3-t-butyl-1, 2-dimethoxybenzene. Four to seven compounds were identified as blood components of Ai pian, and L-borneol, L-camphor, and borneol acetate were common prototypes with relative compositions from 13.720 to 36.509%, 2.336 to 5.219%, and 0.401 to 1.188%, respectively. Methyl oleate was a common metabolic component with a relative concentration of 0.021 to 0.446%. The chemical composition and blood components of Ai pian were complex, and its efficacy was related to synergism between several components including L-borneol, L-camphor, and borneol acetate. Therefore, detecting multiple index components of Ai pian is essential for quality control.

中文翻译：

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通过气相色谱 - 质谱（GC-MS）测定药物和治疗小鼠血液中的挥发物，对来自香脂的艾片栽培区域进行地理分析

摘要 艾片，来源于Blumea balsamifera (L.) DC。具有多种药效和复杂的成分。本研究的目的是通过不同地区的样本分析艾片的化学成分，探索治疗小鼠的化学成分与其血液成分之间的差异，以阐明其功效是否与多种成分的协同作用有关，以提供参考。合理的质量控制。用气相色谱-质谱联用仪(GC-MS)测定并比较了镇丰、望漠、罗店县7批艾片30分钟后小鼠空白和含艾片血清的化学成分；贵州省；和天峨县；和广西省。鉴定出16-22个艾片化合物，包括L-冰片、L-樟脑、醋酸冰片、L-芳樟醇、α-gurjunene和3-t-丁基-1,2-二甲氧基苯等14种常见化合物。鉴定出4～7种化合物为艾片的血液成分，L-冰片、L-樟脑和醋酸冰片为常见原型，相对组成分别为13.720～36.509%、2.336～5.219%和0.401～1.188%。油酸甲酯是一种常见的代谢成分，相对浓度为 0.021% 至 0.446%。艾片的化学成分和血液成分复杂，其药效与左旋冰片、左旋樟脑、醋酸冰片等多种成分协同作用有关。因此，检测爱片的多个指标成分对于质量控制至关重要。和 3-叔丁基-1, 2-二甲氧基苯。鉴定出4～7种化合物为艾片的血液成分，L-冰片、L-樟脑和醋酸冰片为常见原型，相对组成分别为13.720～36.509%、2.336～5.219%和0.401～1.188%。油酸甲酯是一种常见的代谢成分，相对浓度为 0.021% 至 0.446%。艾片的化学成分和血液成分复杂，其药效与左旋冰片、左旋樟脑、醋酸冰片等多种成分协同作用有关。因此，检测爱片的多个指标成分对于质量控制至关重要。和 3-叔丁基-1, 2-二甲氧基苯。鉴定出4～7种化合物为艾片的血液成分，L-冰片、L-樟脑和醋酸冰片为常见原型，相对组成分别为13.720～36.509%、2.336～5.219%和0.401～1.188%。油酸甲酯是一种常见的代谢成分，相对浓度为 0.021% 至 0.446%。艾片的化学成分和血液成分复杂，其药效与左旋冰片、左旋樟脑、醋酸冰片等多种成分协同作用有关。因此，检测爱片的多个指标成分对于质量控制至关重要。醋酸冰片和冰片是常见的原型，相对组成分别为 13.720 至 36.509%、2.336 至 5.219% 和 0.401 至 1.188%。油酸甲酯是一种常见的代谢成分，相对浓度为 0.021% 至 0.446%。艾片的化学成分和血液成分复杂，其药效与左旋冰片、左旋樟脑、醋酸冰片等多种成分协同作用有关。因此，检测爱片的多个指标成分对于质量控制至关重要。醋酸冰片和冰片是常见的原型，相对组成分别为 13.720 至 36.509%、2.336 至 5.219% 和 0.401 至 1.188%。油酸甲酯是一种常见的代谢成分，相对浓度为 0.021% 至 0.446%。艾片的化学成分和血液成分复杂，其药效与左旋冰片、左旋樟脑、醋酸冰片等多种成分协同作用有关。因此，检测爱片的多个指标成分对于质量控制至关重要。L-樟脑和醋酸冰片。因此，检测爱片的多个指标成分对于质量控制至关重要。L-樟脑和醋酸冰片。因此，检测爱片的多个指标成分对于质量控制至关重要。