Surface soils were collected near a chemical industrial park in the present study and in vitro inhalation and ingestion bioaccessibility of soilborne lead, cadmium, arsenic and chromium was evaluated using various in vitro bioaccessibility procedures including simulated lung fluid (SLF), artificial lysosomal fluid (ALF), modified Gamble solution (MGS), Solubility/Bioaccessibility Research Consortium (SBRC) procedure, and in vitro gastrointestinal (IVG) procedure. The in vitro inhalation and ingestion bioaccessibility of toxic elements showed elemental dependence and differed greatly among SBRC, IVG, SLF, ALF and MGS. The non-carcinogenic and lifetime carcinogenic risks of soilborne toxic elements based on the bioaccessible contents via ingestion and inhalation exposure were within the acceptable level. The present study reveals that the in vitro bioaccessibility of toxic elements was influenced greatly by the current in vitro bioaccessibility procedures, which resulted in great differences on the risk-based assessment via inhalation and oral ingestion exposure.

在本研究中，在化学工业园区附近收集表层土壤  ，并使用各种体外 生物可及性程序（包括模拟肺液（SLF），人工溶酶体液（ALF））评估土壤中铅，镉，砷和铬的体外吸入和摄入生物可及性。  ），改良的Gamble溶液（MGS），溶解度/生物可及性研究联盟（SBRC）程序和 体外 胃肠道（IVG）程序。在 体外 吸入和摄入有毒元素的生物可及性显示出元素依赖性，并且在SBRC，IVG，SLF，ALF和MGS之间存在很大差异。根据通过食入和吸入暴露途径可生物获取的含量，土壤传播的有毒元素的非致癌和终生致癌风险在可接受的范围内。本研究表明，  有毒元素的体外生物可及性受当前体外 生物可及性程序的影响很大 ，这导致通过吸入和口服摄入暴露进行基于风险的评估存在很大差异。