A mixture of taxols was prepared from 10‐deacetyl‐7‐xylosyltaxanes by three‐step reactions: redox, acetylation, and deacetylation. The mixture was separated by column chromatography on silica gel to afford Taxol, Taxol B (Cephalomannine) and Taxol C. The mixture of Taxol B and Taxol C was converted to Docetaxel by Schwartz's reagent. The structures of Taxol and Docetaxel were characterized by HPLC, 1H‐NMR, 13C‐NMR and MS. This synthetic process has expanded the source of biomass for the chemical semi‐synthesis of Taxol and Docetaxel, reduced the production costs, and increased the biomass resource of taxanes.

中文翻译：

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10-脱乙酰基-7-木糖基紫杉烷合成紫杉醇和多西紫杉醇

通过三步反应：氧化还原、乙酰化和脱乙酰化，由 10-脱乙酰基-7-木糖基紫杉烷制备紫杉醇混合物。混合物通过硅胶柱色谱分离，得到紫杉醇、紫杉醇B(头孢菌素)和紫杉醇C。紫杉醇B和紫杉醇C的混合物通过施瓦茨试剂转化为多西紫杉醇。紫杉醇和多西紫杉醇的结构通过 HPLC、1H-NMR、13C-NMR 和 MS 表征。该合成工艺扩大了紫杉醇和多西紫杉醇化学半合成的生物质来源，降低了生产成本，增加了紫杉烷的生物质资源。